Ph I SU011248 + Irinotecan in Treatment of Pts w MG

Inclusion Criteria:

* Pts confirmed GBM, GS, AA, AO \& AOA w recurrent disease following standard therapy consisting of at least external beam XRT \& temo chemo
* Pts not had tumor biopsy \<1 week/surgical resection \<2 weeks prior to starting study drug
* Pts should be on non-increasing dose of steroids \>7 days prior to obtaining baseline Gd-MRI of brain
* Age \>18yrs
* KPS \>70
* ANC \>1.5 x 10 9/L
* Hgb \>9 g/dL
* Platelets \>100 x 10 9/L
* AST/SGOT \& ALT/SGPT \<2.5 x ULN
* Serum bilirubin \<1.5 x ULN
* Serum CA \<12 mg/dL
* Serum creatinine \<1.5 x ULN/measured 24-hr CrCl\>50mL/min/1.73m\^2
* Pt has ability to understand \& provide signed informed consent that fulfills IRB guidelines

Exclusion Criteria:

* Prior gr3/\>toxicity/failure to CPT-11 therapy
* Prior Sunitinib malate therapy
* Concurrent administration of EIAEDs
* Major surgery \<2 weeks of enrollment
* History of impaired cardiac function
* Other clinically significant cardiac diseases
* Uncontrolled diabetes
* Active/uncontrolled infection requiring intravenous antibiotics
* Impairment of GI function/GI disease that may significantly alter absorption of Sunitinib malate Sutent
* Acute/chronic liver/renal disease
* Cerebrovascular accident/transient ischemic attack \<6mths of study enrollment
* Pulmonary embolism \<6mths of study enrollment
* Pre-existing thyroid abnormality w thyroid function that can not be maintained in normal range w medication
* Pts taking warfarin sodium
* Pts have received chemo ≤4wks to starting study drug unless they have fully recovered from all anticipated side effects of such therapy
* Pts have received immunotherapy ≤2wks to starting study drug/have not recovered from side effects of such therapy
* Pts have received investigational drugs ≤2wks to starting study drug unless they have fully recovered from all anticipated side effects of such therapy
* Pts have received XRT ≤4wks to starting study drug unless they have fully recovered from all anticipated side effects of such therapy
* Pts have undergone major non-CNS surgery ≤2wks to starting study drug/pts who have not recovered from side effects of such therapy
* Cardiac pacemaker
* Ferromagnetic metal implants other than those approved as safe for use in MR scanners
* Claustrophobia
* Obesity
* Female pts who are pregnant/breast feeding/adults of reproductive potential not employing effective method of birth control
* Known diagnosis of HIV
* History of another primary malignancy that is currently clinically significant/currently requiring active intervention
* Pts unwilling to/unable to comply w protocol
* Existing intra-tumoral hemorrhage
* Concurrent participation in another clinical trial except for supportive care/non-treatment trials
* Other severe acute/chronic medical/psychiatric condition/lab abnormality that may increase risk associated w study participation/study drug administration/ may interfere w interpretation of study results, \& in judgment of investigator would make subject inappropriate for entry into this study