Clinical trial · Observational
Studying the Effect of Freeze-Dried Table Grape Powder on Blood Estrogen Levels in Postmenopausal Women
Evaluation of the Aromatase Inhibition Potential of Standardized Grape Extract
NCT00611104CI-TRIAL-00080849completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Estrogen can cause the growth of breast cancer cells. Studying samples of blood and urine in the laboratory from participants receiving freeze-dried table grape powder may help doctors understand the effect of this drug on blood estrogen levels. PURPOSE: This clinical trial is studying the effect of freeze-dried table grape powder on blood estrogen levels in postmenopausal women.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| laboratory biomarker analysis | Other | — | UNRESOLVED |
| pharmacological study | Other | — | UNRESOLVED |
| standardized freeze-dried table grape powder | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Serum levels of plasma estrone (E1), estradiol, E1-conjugates, and E1-sulfates
- measure
- Bioavailability of the freeze-dried table grape powder in humans
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 120 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Participant in the Mayo Mammography Health Study * Has consented to provide baseline mammogram for digitization PATIENT CHARACTERISTICS: * ECOG performance status 0-1 * Female * Postmenopausal (defined as women who have had both ovaries removed or no menstrual period for at least 12 consecutive months) * Able to give informed consent and complete food records alone or with assistance * Willing to provide research blood and urine samples * Must be a non-smoker * Willing to maintain current weight * No history of breast ductal carcinoma in situ or any other cancer, except basal cell or squamous cell skin cancer or lobular carcinoma in situ * No history of allergic or other adverse reaction to grapes * No history of diabetes or glucose intolerance PRIOR CONCURRENT THERAPY: * No concurrent hormone therapy, including estradiol, estrone, or progestins
References
Publications (0)
Data not yet available
No reference posted for this study.