Clinical trial · Observational
Magnetic Resonance Imaging in Patients With Breast Cancer
Magnetic Resonance Imaging (MRI) for Preoperative Staging of Patients With Invasive Lobular Carcinoma of the Breast
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical research study is to learn how often magnetic resonance imaging (MRI) of the breast locates additional areas of cancer in the breast of patients with lobular cancer as well as in the breasts of young breast cancer patients (less than age 40 years). Researchers also hope to learn how often the results of the MRI changes the type of surgical treatment that is recommended and understand the costs associated with using MRI in the diagnostic process. Researchers also want to use a different way of looking at the MRI scans to learn if they can more easily learn the difference between a cyst and a tumor.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MRI | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Breast MRI
- description
- Magnetic resonance imaging (MRI) of breast for patients with invasive lobular carcinoma of the breast.
- interventionNames
- Procedure: MRI
Primary outcomes (1)
- measure
- Change in surgical management of patients with invasive lobular carcinoma of the breast and young breast cancer patients as a result of preoperative breast MRI
- timeFrame
- 3 years (# of times MRI changes type of surgical treatment recommended)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with pure invasive lobular carcinoma or mixed invasive ductal-lobular carcinoma with the ductal component not greater that 25% OR patients under the age of 40 at diagnosis, irrespective of tumor histology 2. For women with invasive lobular carcinoma, if the pathology report from the diagnostic biopsy states that they have "predominantly" lobular histology or lobular cancer with "focal" areas/nests of ductal carcinoma, these cases will automatically be assumed to have at least 75% lobular component. 3. Women with multifocal or multicentric breast cancer are eligible if any one of the biopsy confirmed tumors meets the histologic designations outlined in Inclusion criteria #1 and #2 above. 4. Must be able to complete the MR examination within 30 days of mammography and ultrasound of the breast. 5. Age \>18 years 6. Surgery planned at MDACC 7. Eastern Cooperative Oncology Group (ECOG) status 0-2 8. Creatinine and glomerular filtration rate measured or calculated within 2 weeks of MRI date Exclusion Criteria: 1. Patients receiving neoadjuvant chemotherapy 2. Patients with pacemakers 3. Patients with severe claustrophobia 4. Obese patients exceeding the equipment weight limits and/or the circumference of the MRI portal 5. Interval between MRI and conventional locoregional staging studies (mammography/breast US) greater than 30 days. 6. Known allergy to gadolinium 7. Patients with clips/prostheses/implanted devices that are not MRI compatible 8. Compromised renal function, with a measured or calculated glomerular filtration rate of less than 60 ml/min/1.73m\^2.
References
Publications (0)
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