Clinical trial · Interventional
Pilot Studie of Lipiodol Demarcation of the Tumour in Bladder Cancer
Lipiodol Demarcation of the Bladder Tumour in Adaptive Image-guided Radiotherapy: A Pilot Study. (Danish: Lipiodol Til Markering af blæretumoren i Forbindelse Med Adaptiv Billedvejledt strålebehandling: Et Pilotstudie.)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Rationale: Bladder tumours are often not visible on X-ray based image-modalities during planning and treatment of Radiotherapy. Purpose: To determine if a single contrast (Lipiodol) demarcation of the bladder tumour before treatment is feasible and visible on multiple X-ray based image-modalities during Radiotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder Cancer | Malignant Bladder Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lipiodol demarcation of the bladder tumour | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- 1
- interventionNames
- Other: Lipiodol demarcation of the bladder tumour
Primary outcomes (2)
- measure
- Is Lipiodol demarcation visible on the planning CT (Feasibility)
- timeFrame
- Before Radiotherapy
- measure
- Is Lipiodol visible on CBCT during Radiotherapy treatment (duration)
- timeFrame
- Daily the first week, then two times a week during Radiotherapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed primary muscle invasive transitional cell carcinoma of the Bladder. T1-4a, N0-1, M0. * Non-operable or refuse operation. * Eligible for curative Radiotherapy. * Oral and written informed consent. * Fertile women must have a negative pregnancy test before inclusion or use contraceptive pills or intrauterine device. * Ongoing beta blocker treatment is paused before Lipiodol injection. Exclusion Criteria: * Known metabolic disorder (hyperthyroidism, goiter) * Allergy towards iodine. * Pregnancy / breast-feeding * Performance status ECOG \> 2
References
Publications (1)
- DERIVEDSondergaard J, Olsen KO, Muren LP, Elstrom UV, Grau C, Hoyer M. A study of image-guided radiotherapy of bladder cancer based on lipiodol injection in the bladder wall. Acta Oncol. 2010 Oct;49(7):1109-15. doi: 10.3109/02841861003789491. PMID 20429726