Clinical trial · Interventional
A Study for Patients With Non-Squamous Non-Small Cell Lung Cancer
Pemetrexed With Simplified Folate and Dexamethasone Supplementation Versus Pemetrexed With Standard Supplementation as Second-line Chemotherapy for Patients With Non-squamous Non-small Cell Lung Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Chemotherapy for patients with non-squamous non-small cell lung cancer. Patients are given folic acid, vitamin B12 and steroids, both before and during treatment, to reduce the side effects associated with pemetrexed. The aim is whether it is possible to simplify the folic acid and steroid schedule without increasing toxicity.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non Small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| dexamethasone | Drug | Dexamethasone | ALIAS |
| Folic acid | Dietary Supplement | — | UNRESOLVED |
| pemetrexed | Drug | Pemetrexed | ALIAS |
| Vitamin B12 | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Standard Vitamin and Steroid Schedule + Pemetrexed
- description
- Standard vitamin and steroid schedule that is used with pemetrexed consisting of a minimum of 5 daily doses of folic acid before first pemetrexed dose and dexamethasone on day before, day of, and day after treatment.
- interventionNames
- Drug: pemetrexed
- Dietary Supplement: Folic acid
- Dietary Supplement: Vitamin B12
- Drug: dexamethasone
- type
- EXPERIMENTAL
- label
- Simplified Vitamin and Steroid Schedule + Pemetrexed
- description
- Simplified vitamin and steroid schedule to be used with pemetrexed consisting of 2 daily doses of folic acid before first pemetrexed dose and dexamethasone on day of treatment only.
- interventionNames
- Drug: pemetrexed
- Dietary Supplement: Folic Acid
- Dietary Supplement: Vitamin B12
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologic or cytologic diagnosis of non-small cell lung cancer (NSCLC) with locally advanced or metastatic disease (Stage IIIA, IIIB or IV)that is of non-squamous histology * Patients must have failed only one prior chemotherapy regime and must be considered eligible for further chemotherapy following progression of their disease. * Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2 * Adequate organ function Exclusion Criteria: * Concurrent administration of any other anti-tumor therapy * Other co-existing malignancies * Pregnancy or breast feeding * Serious concomitant disorders * Inability or unwillingness to take folic acid or vitamin B12 supplementation
References
Publications (0)
Data not yet available