Clinical trial · Interventional
Brassica Vegetables or Indole-3-Carbinol in Treating Patients With PSA Recurrence After Surgery for Prostate Cancer
Effects of Bassica or Indole-3-Carbinol on Prostatectomy Patients With PSA Recurrence
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Eating a diet high in vegetables may lower the risk of some types of cancer. Brassica vegetables (such as cabbages, kale, broccoli, Brussels sprouts, and cauliflower) and indole-3-carbinol (a substance found in cruciferous vegetables) may help lower the risk of prostate cancer recurrence. PURPOSE: This randomized clinical trial is studying the side effects and how well Brassica vegetables work compared with indole-3-carbinol in treating patients with PSA recurrence after surgery for prostate cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (7)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| adjuvant therapy | Procedure | — | UNRESOLVED |
| behavioral dietary intervention | Behavioral | — | UNRESOLVED |
| Brassica vegetable | Dietary Supplement | — | UNRESOLVED |
| counseling intervention | Other | — | UNRESOLVED |
| indole-3-carbinol | Drug | — | UNRESOLVED |
| medical chart review | Other | — | UNRESOLVED |
| questionnaire administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Brassica Vegetables Diet Intervention
- interventionNames
- Behavioral: behavioral dietary intervention
- Dietary Supplement: Brassica vegetable
- Drug: indole-3-carbinol
- Other: counseling intervention
- Other: medical chart review
- Other: questionnaire administration
- Procedure: adjuvant therapy
- type
- EXPERIMENTAL
- label
- Pill
- interventionNames
- Drug: indole-3-carbinol
- Other: counseling intervention
- Other: medical chart review
- Other: questionnaire administration
- Procedure: adjuvant therapy
Primary outcomes (3)
- measure
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria:
* Diagnosis of prostate cancer with PSA recurrence after prostatectomy
* PSA recurrence is defined as two consecutively rising PSA tests ≥ 8 weeks since the post-surgical nadir, with a minimal interval of 2 weeks between tests and at least 1 PSA test \> 0.4 ng/mL
Exclusion Criteria:
* Life expectancy ≥ 9 months
* No predictors of poor adherence (e.g., erratic life-style, mental incompetence)
PRIOR CONCURRENT THERAPY:
* See Disease Characteristics
* No other concurrent Brassica vegetable consumption \> 1 serving/day
* No other concurrent indole-3-carbinol supplements
* No endocrine or radiation treatment within past 4 weeks
* No other scheduled treatment during study intervention
* Concurrent prescription medications during the trial allowed
* At least 2 weeks since prior and no concurrent vitamin or herbal supplement use
* Patients refusing to stop non-study supplements will be asked to maintain constant useReferences
Publications (0)
Data not yet available