Clinical trial · Interventional
Prevention of Acute Voiding Difficulty After Radical Proctectomy
Prevention of Acute Voiding Difficulty After Radical Proctectomy for Rectal Cancer With Tamsulosin
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Various adrenergic blockers are used for acute voiding difficulty after proctectomy. Recently, a selective alpha5-adrenergic blocker, Tamsulosin has been reported to have benefit in reducing urinary symptom score and in reducing the rate of intermittent self-catheterization for patients with rectal cancer after radical proctectomy. This study is to evaluate the efficacy of pharmacologic prevention to ameliorate the incidence of postoperative urinary dysfunction.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
| Urinary Retention | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Tamsulosin | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- 1
- type
- EXPERIMENTAL
- label
- 2
- description
- oral administration of Tamsulosin
- interventionNames
- Drug: Tamsulosin
Primary outcomes (1)
- measure
- Re-insertion rate of urinary catheter after removal
- timeFrame
- after removal of urinary catheter
Secondary outcomes (1)
- measure
- Scores of IPSS (International Prostatic Symptom Score) and the results of uroflowmetry
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients between 20-80 years old in general good health * Patient willing to participate in the study * Patient who understands and accepts to sign the informed consent form * Patient who received proctectomy for rectal cancer located 15 cm or less of the anal verge Exclusion Criteria: * Documented problem of preoperative urinary dysfunction * Any post-surgery change in patient condition which requires insertion of urinary catheter after surgery * Past history of recurrent urinary tract infection or malignancy of urinary system organs * Past history of surgery for urinary system organs * Current administration of Finasteride or Dutasteride * Liver dysfunction (SGOT or SGPT 100 IU/L or more) * Kidney dysfunction (serum Creatinine 3mg/dl or more)
References
Publications (1)
- DERIVEDEllahi A, Stewart F, Kidd EA, Griffiths R, Fernandez R, Omar MI. Strategies for the removal of short-term indwelling urethral catheters in adults. Cochrane Database Syst Rev. 2021 Jun 29;6(6):CD004011. doi: 10.1002/14651858.CD004011.pub4. PMID 34184246