Structural Imaging and Cognitive Functions in Adult Stem Cell Transplant Recipients Treated With Chemotherapy Alone or in Combination With Radiotherapy

Inclusion Criteria:

* Diagnosed with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), acute undifferentiated or biphenotypic leukemia, myelodysplastic syndrome (MDS), Hodgkin's lymphoma, (HL) or non-Hodgkin's lymphoma (NHL), and in complete remission at the time of enrollment
* Are scheduled to undergo conditioning treatment with (1) total body radiation (TBI) and chemotherapy or (2) chemotherapy alone prior to receiving a myeloablative allogeneic HSCT
* Between 18 and 70 years of age.
* Are English speaking.
* Have capacity to give consent.

Healthy Control Inclusion Criteria:

* Have no diagnosis of cancer except basal cell carcinoma
* Between 18 and 70 years of age.
* Are English speaking.
* Have capacity to give consent

Exclusion Criteria:

* Patients with signs and/or symptoms of central nervous system disease as determined by their physician or by a brain MRI, either at the time of enrollment or during the study period.
* With disease progression at the time of enrollment or during the study period
* With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia
* With a history of a neurological disorder, neurodegenerative disease, or traumatic brain injury with loss of consciousness
* With standard contraindications to MRI examinations

Healthy Control Exclusion Criteria:

* Exposure to chemotherapy or radiation therapy for any medical condition
* With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia
* With a history of neurological disorders, neurodegenerative disease, or traumatic brain injury with loss of consciousness
* With standard contraindications to MRI examinations