Vaccine Therapy in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer

Inclusion Criteria:

* Adults over the age of 21 capable of giving informed consent
* Pathologically confirmed non-small cell lung cancer (NSCLC)
* Stage IIIB, IV, or recurrent disease
* Progressive disease despite one or more prior chemotherapy regimens as standard of care OR patient refuses standard chemotherapy
* Measurable metastatic disease by RECIST guidelines
* Patients with a major endobronchial lesion in the segmental, lobar, or mainstem bronchus with complete obstruction of the airway may be eligible for bronchoscopic injection provided there is no evidence of respiratory failure (defined as SaO\_2 \> 90% on room air, PCO\_2 \< 45 mm Hg, or FEV\_1 \> 1.0 L)
* Patients with an endobronchial lesion in the segmental bronchus with variable stenosis (not completely obstructed) and not amenable to standard palliative airway treatments (i.e., laser and stenting) may be eligible for bronchoscopic injection if there is no evidence of respiratory failure (defined as SaO\_2 \> 90% on room air, PCO\_2 \< 45 mm Hg, or FEV\_1 \> 1.0 liters)
* Patients with bullous disease may undergo CT-guided transthoracic injection provided the targeted tumor has an intended needle path without crossing bullae
* ECOG performance status 0-2
* BUN ≤ 40 OR serum creatinine ≤ 2
* Serum total bilirubin ≤ 1.5 OR serum transaminases ≤ 2.5 times upper limit of normal (ULN)
* Negative pregnancy test
* Fertile patients must use effective contraception
* More than 14 days since prior acute therapy for viral, bacterial, or fungal infections
* More than 30 days since prior and no concurrent corticosteroids
* More than 30 days since prior radiotherapy, chemotherapy, or noncytotoxic investigational agents

Exclusion Criteria:

* active CNS metastasis (i.e., progression of CNS disease during the past 30 days without intervention)
* evidence of coagulopathy, defined as PT and/or PTT ≤ 1.5 times ULN OR platelets ≥ 100,000/mm\^3
* evidence of leukoplakia, defined as absolute neutrophil count ≥ 1,500/mm\^3
* evidence of respiratory failure (defined as SaO\_2 \> 90% on room air, PCO\_2 \< 45 mm Hg, or FEV\_1 \> 1.0 L)
* NYHA class III-IV cardiac disease within the past year
* myocardial infarction within the past year
* comorbid disease or medical condition that would impair the ability of the patient to receive or comply with the study protocol
* acute viral, bacterial, or fungal infection that requires specific therapy
* HIV positivity
* hypersensitivity to any reagents used in the study
* signs or symptoms of acute adenoviral infection (i.e., conjunctivitis or documented adenoviral upper respiratory infection)
* prior or concurrent evidence of autoimmune disease
* pregnant or nursing
* prior organ allograft