Clinical trial · Interventional
Dynamic Contrast Enhanced MRI(DCE-MRI)of Bone Tumors
NCT00598741CI-TRIAL-00014228completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to see whether fast imaging with MRI and the usual contrast material used for MRI, predicts which patients will do well with treatment. Some studies suggest that MRIs done right before surgery may be able to tell how much of the cancer was killed by the chemotherapy. This study will see if this is true in patients with osteogenic sarcoma (OS) and Ewing's sarcoma (ES). This study will also see if MRIs done early in treatment can tell if the chemotherapy is working.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bone Tumor | Bone Neoplasm | ALIAS | 0.90 |
| Sarcoma | Sarcoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| DCE-MRI | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- 1
- interventionNames
- Other: DCE-MRI
Primary outcomes (1)
- measure
- Pts will undergo baseline MRI prior to begin chemotherapy. Bet 18-24 days after beginning chemotherapy, they will undergo second MRI. They will continue chemotherapy and w/in 25 days prior definitive surgery, will undergo another MRI.
- timeFrame
- 8 years
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * All patients with histologically proven diagnoses of OS or Ewing Sarcoma undergoing induction chemotherapy are eligible for study. * Patients/guardians must provide written consent. It is anticipated that many of these patients will be minors and consent will be obtained from their parent/guardian. * The presence of the evaluable primary tumor is required. Exclusion Criteria: * Inability to cooperate for an MRI. * Absence of evaluable primary tumor * Known reaction to Gd-DTPA * Pre-operative radiation to primary tumor site * Contraindication to MRI 1. Pacemaker 2. Aneurysmal clips 3. Metal implants in field of view 4. Any other conditions that result in patients not being appropriate for MRI. study 5. Pregnancy 6. Age and mental status wherein he/she is able to cooperate for MRI study 7. Unusual histopathologic subvariants (radiation induced, Paget's disease, hereditary RB)
References
Publications (0)
Data not yet available
No reference posted for this study.