Clinical trial · Interventional
Improving Functional Outcomes in Patients With Unilateral Vocal Cord Paralysis: Assessment of Adaptation Using Functional Magnetic Resonance Imaging
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to see how the brain re-learns to control the larynx in speaking and swallowing when undergoing surgical rehabilitation in the form of either thyroplasty or vocal fold augmentation for unilateral vocal cord paralysis. What is needed is information on how the brain re-learns to control speaking and swallowing so that we can eventually learn how to help patients re-learn faster after their procedure. Functional Magnetic Resonance Imaging (or fMRI) will allow us to image your brain as you speak and swallow. We will produce "brain maps" for speaking, swallowing and hand movements.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Intrathoracic Malignancies | — | UNRESOLVED | — |
| Unilateral Vocal Cord Paralysis | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| undergo voice evaluation and fMRI prior | Other | — | UNRESOLVED |
| voice evaluation and fMRI | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 1
- description
- voice evaluation and fMRI prior to surgical rehabilitation of UVCP
- interventionNames
- Other: voice evaluation and fMRI
- type
- OTHER
- label
- 2
- description
- Healthy volunteers-voice evaluation and fMRI
- interventionNames
- Other: undergo voice evaluation and fMRI prior
Primary outcomes (1)
- measure
- utilize fMRI technique to characterize adaptation to alterations in vocal cord morphology, speech & swallowing function in patients with UVCP undergoing procedure for rehab of speech and swallowing, either type I thyroplasty or vocal fold augment.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with UVCP undergoing type I thyroplasty or vocal fold augmentation for rehabilitation of speech and swallowing. * Inclusion criteria for the healthy subjects: * From age 18-85 Exclusion Criteria: * for the UVCP patients includes the following: * History of significant psychiatric condition (e.g. schizophrenia, obsessive-compulsive disorder, significant dementia), * History of the following neurological conditions: CVA, seizure disorders, demyelinating conditions, systemic neuromuscular disorders, cerebral palsy, Alzheimer's disease. * History of previous moderate to severe traumatic brain injury. * History of significant cardiovascular, gastrointestinal or renal disease (e.g. myocardial infarction within the previous 12 months, significant vaso-occlusive disease, severe or advanced asthma, or renal compromise) * History of achalasia * History of dysphagia, odynophagia, or aphasia unrelated to present illness. * History of significant claustrophobic reactions. * Standard contraindications to MR examinations (e.g. implanted stimulators, pregnancy). Exclusion criteria for the healthy subjects includes the following: * All of the conditions listed for the UVCP patients. * Significant surgery or previous radiation therapy to the head and neck. * History of other neoplasms involving the brain, head and neck, or gastrointestinal system.
References
Publications (0)
Data not yet available