Clinical trial · Interventional
Imaging Brain Tumors With FACBC and Methionine
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research protocol makes pictures of brain tumors. The pictures are made with a positron emission tomography (PET) scanner. PET scans use radioactivity to "see" cancer cells. We are using a new kind of PET scan. The new PET scan is called \[18F\]-FACBC PET. We will compare this to the standard PET scan. The standard PET scan is called \[11C\]-methionine PET. We expect these pictures will give us information about your tumor. We also hope to collect information about the amount of radioactivity exposure. We will measure radioactivity exposure to your tumor, brain and other organs. The research study results will be used to support the submission of an investigational new drug (IND) application to the Food and Drug Administration (FDA).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Cancer | Malignant Brain Neoplasm | ALIAS | 0.90 |
| CNS Cancer | Malignant Central Nervous System Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| FACBC, Methionine | Drug | — | UNRESOLVED |
| PET Scan | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- 1
- interventionNames
- Drug: FACBC, Methionine
- Other: PET Scan
Primary outcomes (1)
- measure
- Maximum Standardized Uptake Value of 3-[18F]-FACBC
- timeFrame
- Duration of scan, an average of 1 hour
- description
- Determine clearance of 3-\[18F\]-FACBC in different tissues/organs of body.
Secondary outcomes (1)
- measure
- Rate of 18F-Fluciclovine Transport (k1) Into Tumors
- timeFrame
- Duration of scan, an average of 1 hour
- description
- Look for potential correlations bet subsequent MR \& PET results obtained from patients enrolled and patients' subsequent medical treatment, progression of tumor \& survival.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Registered patient at MSKCC. * Child-bearing age females must be non-pregnant, non-lactating, and must be using adequate contraception or surgically sterile. * Karnofsky score of 60 or greater. * Children that can sit still for 60-90 minutes, without sedation, will be included in this protocol. Exclusion Criteria: * Patient cannot tolerate lying still for 90 minute sessions in the PET tomograph.
References
Publications (0)
Data not yet available