Dose-Escalation Study of Intensity-Modulated Radiotherapy(IMRT)in Patients With Unresectable Pancreatic Cancer

Inclusion Criteria:

* Is the patient 18 years of age or older.
* Does the patient have histologically or cytologically proven carcinoma of the pancreas
* Is the tumor unresectable or medically inoperable
* Does the patient have a Zubrod performance status of ≤ 2 (appendix I).
* Does the patient have an absolute neutrophil count of ≥ 1500/mm3, and platelets ≥ 100,000/mm3
* Does the patient have adequate renal function (creatinine \< 2 mg/dl) and hepatic function (bilirubin \< 3 mg/dl), with relief of biliary obstruction if present
* Is the patient free of significant co-morbid conditions that would preclude safe administration or completion of protocol therapy
* If the patient is of reproductive potential, has he or she agreed to use an effective method of contraception during treatment on this trial and for 6 months after treatment
* Is the patient aware of the investigational nature of the therapy such that they can provide written informed consent

Exclusion Criteria:

* Does the patient have a neuroendocrine tumor of the pancreas
* Does the patient have metastatic disease
* Does the patient have a history of abdominal radiation therapy
* Is there history of more than 1 month of therapy with single agent gemcitabine
* Has the patient used any investigational agent in the month before enrollment into the study