Clinical trial · Observational
Carotid Artery Disease in Childhood Cancer Survivors
Carotid Artery Disease in Long-Term Survivors of Childhood Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Slow Accrual.
Summary
Brief summary (as posted)
The goal of this clinical research study is to find out if long-term survivors of childhood head or neck cancer, who received radiation therapy as part of the overall treatment plan, are at increased risk of thickening or blockage of the carotid arteries (the major blood vessels in the neck). Researchers also want to find out if other medical conditions, such as high blood sugar, high blood cholesterol, or history of tobacco use may contribute to the thickening or blockage of the carotid arteries.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pediatric Cancers | Childhood Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Carotid Ultrasound | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Carotid Ultrasound
- description
- Carotid Ultrasound: Irradiated and non-irradiated sides of the neck in long-term survivors of pediatric cancers who received unilateral radiation therapy involving the carotid artery as part of their treatment
- interventionNames
- Procedure: Carotid Ultrasound
Primary outcomes (1)
- measure
- Patients with Carotid intima-media thickening (IMT)
- timeFrame
- Carotid ultrasound testing and laboratory examinations performed at time of routinely scheduled yearly appointment.
Secondary outcomes (1)
- measure
- Patients with Carotid artery stenosis (CAS)
- timeFrame
- Carotid ultrasound testing and laboratory examinations performed at time of routinely scheduled yearly appointment.
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 21 Years
Show eligibility criteria text
Inclusion Criteria: 1. Subjects must have been less than 21 years of age at time of initial diagnosis. 2. Patients treated at M.D. Anderson Cancer Center for any malignancy (including primary CNS tumors) that required unilateral radiation therapy to the head and neck area and involving the ipsilateral carotid artery as part of the overall treatment plan. 3. Patients must be at least 5 years status post completion of therapy. 4. Must be English speaking, or able to consent through an approved medical language translator. 5. A written informed consent from the patient and/or the patient's legally authorized guardian must be obtained from all patients. Exclusion Criteria: 1. Leukemia patients receiving craniospinal irradiation 2. Non-English speaking subjects for which no appropriate medical translator is available 3. Patients who received head/neck radiation involving both carotid arteries will not be eligible.
References
Publications (0)
Data not yet available