This trial is a multi-center clinical and endoscopic outcomes project involving a single large database of patients with Barrett's Esophagus (BE). The initial goal of this project is to define the incidence and prevalence of cancer and high-grade dysplasia (HGD) in patients with BE. Thus, our hypothesis is that systematic collection of data on the natural history of BE and risk factors for progression of BE will provide useful information to develop a decision model for risk stratification and risk reduction strategies in BE.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
To determine the prevalence and incidence of low grade dysplasia, high grade dysplasia and adenocarcinoma in a large cohort of patients with Barrett's esophagus
timeFrame
up to 10 years
Secondary outcomes (1)
measure
To determine the magnitude of the contribution of selected factors (e.g. age, gender, ethnicity, obesity, tobacco use, alcohol use, ASA/NSAID/PPI use, duration of GERD symptoms, length of BE, HH) to the risk of HGD and CA
timeFrame
up to 10 years
Eligibility
Eligibility (as posted)
Sex
All
Minimum age
18 Years
Maximum age
80 Years
Show eligibility criteria text
Inclusion Criteria:
* Sex: Male and female
* Age: 18-80 years
* Confirmed BE.
Exclusion Criteria:
* Columnar mucosa in the distal esophagus but no intestinal metaplasia on biopsy.
* Patients with BE who have undergone endoscopic ablation therapy or enrolled in chemoprevention trials. Since this is a natural history study, patients enrolled in intervention trials (e.g. those undergoing endoscopic ablation of their BE) will be excluded.
References
Publications (63)
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