Clinical trial · Observational
Unprepped CT Colonography
"CTC of the Unprepped Colon: Optimization & Validation"
NCT00586053CI-TRIAL-00003139completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It is our objective to improve the performance of CTC in the prepared colon, and to validate CTC in the unprepared colon for the detection of colorectal neoplasia. The cost-effectiveness ratio of CTC in the unprepared colon will compare favorably with other colorectal screening test.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (3)
- label
- 1
- description
- 485 patients,who have an average risk (asymptomatic and without colon screening in the last 5 years) or those who have a high risk for colon cancer (strong family history of colon cancer or polyps and/or personal history of colon cancer or polyps).
- label
- 2
- description
- 160 patients, with a known colorectal lesion at or greater than 1 cm.
- label
- 3
- description
- 610 patients, who are of average risk for colon cancer (asymptomatic and no colon cancer screening in the last 5 years).
Primary outcomes (1)
- measure
- To optimize diagnostic performance of CTC in the unprepared colon for colorectal polyp detection using electronic stool subtraction and computer-aided diagnostic techniques.
- timeFrame
- 2000-2009
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: Average risk or higher for colorectal cancer and scheduled for colonoscopy with any of the following indications: * Prior colorectal cancer, prior colorectal adenoma, strong family history of colorectal neoplasia, iron deficiency. * Age ≥ 40 -100 years * Known or highly suspected primary colorectal neoplasms \> 10 mm (n = 160) * Higher than average risk for colorectal cancer and scheduled for colonoscopy with any of the following indications: prior colorectal cancer, prior colorectal adenoma, strong family history of colorectal neoplasia, iron deficiency. Exclusion Criteria: * Less than 1/2 of colorectum remaining * Inflammatory bowel disease (Crohns, Chronic Ulcerative Colitis) * Familial Polyposis * Melena, hematochezia
References
Publications (2)
- RESULTMacCarty RL, Johnson CD, Fletcher JG, Wilson LA. Occult colorectal polyps on CT colonography: implications for surveillance. AJR Am J Roentgenol. 2006 May;186(5):1380-3. doi: 10.2214/AJR.05.0031. PMID 16632734
- RESULTJohnson CD, Fletcher JG, MacCarty RL, Mandrekar JN, Harmsen WS, Limburg PJ, Wilson LA. Effect of slice thickness and primary 2D versus 3D virtual dissection on colorectal lesion detection at CT colonography in 452 asymptomatic adults. AJR Am J Roentgenol. 2007 Sep;189(3):672-80. doi: 10.2214/AJR.07.2354. PMID 17715116