Study of Tumor Necrosis Factor Receptor Fusion Protein Etanercept (Enbrel) in Psoriasis of the Hands and/or Feet

Inclusion Criteria:

* Moderate to severe palmar plantar psoriasis based on physician's global assessment (PGA).
* Between 18 and 70 years of age
* Negative urine pregnancy test at screening and at baseline
* Sexually active men and women of child-bearing potential must agree to use a medically accepted form of contraception (birth control) during the exclusionary medicine wash-out period and throughout the study.
* Ability to self inject study drug or have a designee who can do so
* Capable of understanding and giving written voluntary informed consent

Exclusion Criteria:

* Previous treatment with Enbrel® (etanercept) or similar drugs
* Receipt of investigational drugs or "biologics" within 4 weeks of the screening visit.
* Evidence of skin conditions (e.g. eczema) other than psoriasis that would interfere with evaluations of the study medication.
* Receipt of any biologic medication within the previous 6 months that resulted in a decreased white blood cell count (cells to help fight infections)
* Ultraviolet light treatment (e.g. UVB, PUVA) within one month prior to study drug initiation.
* Receipt of immune-suppressing drugs other than Rheumatrex® (methotrexate) or Soriatane® (acetretin) within 4 weeks prior to the first dose of study drug. Medications you would not be allowed to take during this study include for example, Cytoxan® (cyclosporine), Imuran® (azathioprine), or Sulfazine® (sulfasalazine). If you remain on Rheumatrex® (methotrexate) (≤25 mg/week) or Soriatane® (acitretin) (≤50 mg/day), you must be considered to have inadequate disease control in the opinion of the investigator based on physician's global assessment. You must have been on a stable dose of systemic treatment for at least 1 month prior to the start of the study medication. You will be required to maintain a stable dose of the systemic treatment throughout the study.
* Use of topical steroids in the past 14 days unless they have been used for longer than 14 days and the severity of disease allows entry into study.
* Systemic steroid use (prednisone, etc).
* Prior or concurrent use of Cytoxan® (cyclophosphamide).
* Elevated liver tests; red blood cell count less than normal; decreased platelet count (cells to help with blood clotting); decreased white blood cell count (cells to fight infection); kidney insufficiency
* Any severe adverse event, infection or abnormal laboratory value at the time of the screening visit that would preclude participation in the study
* Presence of a severe infection, less than 30 days prior to the screening visit or between the screening visit and the first dose of study drug
* Pregnant or breast-feeding females.
* Significant concurrent medical diseases including: Uncompensated congestive heart failure (heart is unable to pump as normal): Myocardial infarction (heart attack) within 12 months of screening period; Unstable or stable angina pectoris (chest pains related to your heart); Uncontrolled high blood pressure
* Severe lung disease requiring medical or oxygen therapy
* History of cancer (other than surgically removed skin cancer and in situ cervical cancer) within 5 years of the screening visit
* History of tuberculosis
* Known to be HIV positive
* Rheumatoid arthritis
* Any neurologic demyelinating disease (such as multiple sclerosis or any neurologic disease causing loss of sensation or loss of normal movement) or seizure disorder
* Current or history of psychiatric disease that would interfere with ability to comply with the study protocol or give informed consent.
* History of alcohol or drug abuse.
* Not up-to-date with all immunizations in agreement with the current immunization guidelines
* Significant exposure to the varicella virus (chicken pox)
* Guttate or generalized pustular psoriasis
* Surgery or trauma within a month of baseline considered by the investigator to represent a significant risk or interfere with patient evaluation.