Clinical trial · Interventional
Safety Study of Dacarbazine and Bortezomib in Melanoma and Soft Tissue Sarcoma
Phase I Trial of Dacarbazine and Bortezomib in Melanoma and Soft Tissue Sarcoma
NCT00580320CI-TRIAL-00023553completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Bortezomib will enhance the activity of dacarbazine against melanoma and soft tissue sarcoma. Weekly administration of the combination will prove to be feasible and tolerable at an appropriate dose.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoid Tumors | Neuroendocrine Tumor | ALIAS | 0.90 |
| Melanoma | Melanoma | ONTOLOGY_EXACT | 0.98 |
| Parathyroid Carcinoma | Parathyroid Carcinoma | ONTOLOGY_EXACT | 0.90 |
| Small Cell Carcinoma of the Lung | Lung Small Cell Carcinoma | ALIAS | 0.90 |
| Soft Tissue Sarcoma | Soft Tissue Sarcoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dacarbazine and bortezomib | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- A
- description
- dacarbazine + bortezomib
- interventionNames
- Drug: Dacarbazine and bortezomib
Primary outcomes (1)
- measure
- Safety as measured by serious adverse events
- timeFrame
- 4 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologic diagnosis of cutaneous or mucosal melanoma, soft tissue sarcoma (STS), or an APUD (amine precursor uptake and decarboxylation) tumor. APUD tumors include parathyroid carcinoma, medullary carcinoma of the thyroid, small cell carcinoma of the lung, pheochromocytoma, islet cell tumors, carcinoid tumors, and malignant paraganglioma. * Measurable or evaluable disease not appropriate for resection and/or radiation with curative intent. Patients with small cell carcinoma must have extended stage disease or, if limited stage disease, must have received at least one prior systemic therapy. * Age 18 years or greater * ECOG Performance Status 0 or 1 * Women must be post-menopausal, infertile as the result of a surgical procedure, or willing to use a medically accepted form of birth control (abstinence, hormonal contraceptive, intra-uterine device, diaphragm with spermicide, condon with spermicide) for the duration of study treatment. Men also must agree to use a medically accepted form of birth control for the duration of study treatment. Exclusion Criteria: * Uncontrolled brain metastatic disease * Platelet count \<100 * Absolute neutrophil count \<1.5 * Blood transfusion or hematopoietic growth factors for cytopenia within one month of enrollment. * Calculated or measured (Cockcroft and Gault formula) creatinine clearance \<30 mL/minute * AST \> 3 times the upper limit of normal, unless elevation due to metastatic disease, in which case AST \> 5 times the upper limit of normal * Bilirubin \> 2 mg/mL * Grade 2 or greater peripheral neuropathy * Hypersensitivity to bortezomib, boron, mannitol, or dacarbazine * Pregnant or nursing * Other investigational drugs within 14 days of enrollment * Other medical or other condition(s) that in the opinion of the investigator/sub-investigator might compromise the objectives of the study
References
Publications (0)
Data not yet available
No reference posted for this study.