Clinical trial · Interventional
Effects of Exercise in Combination With Epoetin Alfa
Effects of Exercise in Combination With Epoetin Alfa During High-Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of the study was to determine the effect of Epoetin alfa therapy (short term versus long term) with and without a home-based individualized exercise program that incorporated aerobic and strength resistance training for patients being treated with high-dose chemotherapy and autologous peripheral bloodstem cell transplantation (PBSC T) for multiple myeloma. The endpoints for the study included the number of attempts at and total number of days of stem cell collection, number of RBC and platelet transfusions during the transplantation period, time-to-recovery after transplantation, and response to intensive therapy for multiple myeloma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Multiple Myeloma | Multiple Myeloma | CURATED_EXACT | 0.92 |
Interventions
Interventions (9)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Autologous Peripheral Blood Stem Cell Transplantation | Biological | — | UNRESOLVED |
| Epoetin Alfa | Drug | — | UNRESOLVED |
| Exercise | Behavioral | — | UNRESOLVED |
| Heparin, Low-Molecular-Weight | Drug | — | UNRESOLVED |
| Melphalan | Drug | Melphalan | ALIAS |
| Platelet Transfusion | Biological | — | UNRESOLVED |
| Red Blood Cell Transfusion | Biological | — | UNRESOLVED |
| Thalidomide | Drug | Thalidomide | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Exercise
- description
- Study participants were computer randomized to an individualized exercise program. Participants were stratified within Arm according to whether or not they received thalidomide with heparin, and by age (60 and younger versus older than 60)
- interventionNames
- Drug: Epoetin Alfa
- Behavioral: Exercise
- Biological: Autologous Peripheral Blood Stem Cell Transplantation
- Biological: Red Blood Cell Transfusion
- Drug: Thalidomide
- Drug: Heparin, Low-Molecular-Weight
- Biological: Platelet Transfusion
- Drug: Melphalan
- type
- ACTIVE_COMPARATOR
- label
- usual care
- description
- Study participants were asked to remain as active as possible but not prescribed an individualized exercise program. Participants were stratified within Arm according to whether or not they received thalidomide with heparin, and by age (60 and younger versus older than 60)
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Those who were not at high risk for impending pathologic fracture or cord compression, as determined by magnetic resonance imaging and other radiology reports and physician assessments,and enrolled in Total Therapy treatment protocols were invited to participate in the study. Exclusion Criteria: Patients were excluded if they showed any of the following attributes/conditions: * Inability to understand the intent of the study * Current diagnosis with a major psychiatric illness * Presence of microcytic or macrocytic anemia * Uncontrolled hypertension * Red cell transfusions within 2 weeks; and * Recombinant epoetin alfa within 8 weeks of study enrollment.
References
Publications (0)
Data not yet available