Clinical trial · Observational
Registry for Vascular Anomalies Associated With Coagulopathy
International Registry for Vascular Anomalies Associated With Coagulopathy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
PURPOSE The purpose of this study is to learn more about multifocal lymphangioendotheliomatosis with thrombocytopenia (MLT). MLT is a rare vascular disorder characterized by multiple congenital skin and visceral lesions, profound thrombocytopenia, and gastrointestinal bleeding. The skin lesions may appear red, brown or blue, often misdiagnosed as hemangiomas. The gastrointestinal tract, liver, and lungs are the most common internal organs involved. The severe thrombocytopenia (low platelets) is believed to be the result of platelet trapping within the skin and visceral vascular lesions. Severe and chronic gastrointestinal bleeding is common during infancy and early childhood. Although a relatively newly described entity, MLT was likely previously reported as hemangiomas, blue rubber bleb nevus syndrome, diffuse hemangiomatosis, Kasabach-Merritt phenomenon, and hereditary hemorrhagic telangiectasia. The term cutaneovisceral angiomatosis with thrombocytopenia is also a term used for this same disease. This study is a longitudinal cohort study of MLT to collect detailed clinical data on the distribution of disease, disease severity, and complications. This data will be used to create diagnostic criteria and an evaluation protocol for infants with this disease
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cutaneovisceral Angiomatosis With Thrombocytopenia | — | UNRESOLVED | — |
| Hemangiomas | Hemangioma | ALIAS | 0.90 |
| Multifocal Lymphangioendotheliomatosis With Thrombocytopenia | — | UNRESOLVED | — |
| Vascular Anomaly With Thrombocytopenia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| no intervention | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Vascular Anomaly with Coagulopathy
- description
- All patients diagnosed with Multifocal lymphangioendotheliomatosis with thrombocytopenia (MLT) or with a vascular anomaly with coagulopathy
- interventionNames
- Other: no intervention
Primary outcomes (1)
- measure
- Number of patients with genetic mutations, copy number variations and/or expression analysis
- timeFrame
- After DNA collected and batches are sent for analysis
- description
- Expand knowledge on consensus diagnostic criteria, atypical presentations and long term outcomes of patients with vascular anomalies
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Subjects with a vascular anomaly with coagulopathy Exclusion Criteria: * Subjects without a vascular anomaly with coagulopathy
References
Publications (0)
Data not yet available