Clinical trial · Interventional
The Effect of Grape Seed Extract on Estrogen Levels of Postmenopausal Women
The Effect of Grape Seed Extract on Estrogen Levels of Postmenopausal Women: A Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The role of estrogens in the pathogenesis of breast cancer has been well documented. This has led to the development of "Anti-Estrogens" (selective estrogens receptor modulators and Aromatase Inhibitors), used for treatment and prevention of breast cancer. These agents, however, have significant side effects, which are not acceptable to many healthy high-risk women. There is preliminary evidence that grape seed extract acts as "natural" aromatase inhibitor (1). This study has the potential to quantify the effectiveness of a natural substance that mimics the action of pharmaceutical aromatase inhibitors.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Grape Seed Extract | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- ACTIVE_COMPARATOR
- label
- Grape Seed Extract # 1
- description
- 200 mg \[1 pill\]
- interventionNames
- Dietary Supplement: Grape Seed Extract
- type
- ACTIVE_COMPARATOR
- label
- Grape Seed Extract # 2
- description
- 200 mg \[2 pills\]
- interventionNames
- Dietary Supplement: Grape Seed Extract
- type
- ACTIVE_COMPARATOR
- label
- Grape Seed Extract # 3
- description
- 200 mg \[3 pills\]
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 55 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Age 55 - 75 years * Able to understand and sign a consent form * Postmenopausal (no menstrual period for 1 year or more) * No personal cancer history (except for non-melanoma skin cancer) * No hormone replacement therapy or anti-estrogens within 6 months of baseline Exclusion Criteria: * Known allergy to grapes or grape products * Currently on ACE inhibitors, methotrexate, allopurinol, coumadin (Warfarin, Jantoven), heparin, clopidogrel (Plavix), or cholesterol lowering medication
References
Publications (2)
- BACKGROUNDEng ET, Ye J, Williams D, Phung S, Moore RE, Young MK, Gruntmanis U, Braunstein G, Chen S. Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds. Cancer Res. 2003 Dec 1;63(23):8516-22. PMID 14679019
- BACKGROUNDAmerican Cancer Society. Cancer Facts and Figures 2005. Atlanta, GA: American Cancer Society; 2005.