Clinical trial · Observational
Research Study for Children With a Mother or Sister With Polycystic Ovary Syndrome
Metabolic Syndrome in PCOS: Precursors and Interventions
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this study, we want to find out more about polycystic ovary syndrome(PCOS). This is a common problem in about 7% of teenage girls. Problems may include irregular periods, extra hair on the face, chest and back areas. It seems that PCOS is related to a high level of male hormones and to another problem called metabolic syndrome(MBS). People with MBS may have high blood pressure, low good cholesterol, high blood fats and extra fat around the waist. Girls with MBS are at high risk for getting diabetes and heart disease.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Precursors to PCOS | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Pre-PCOS
- description
- First degree relatives, either sisters or daughters, of women with Polycystic Ovary Syndrome.
- label
- Controls
- description
- Sisters and daughters of women who do not have PCOS
Primary outcomes (1)
- measure
- It is believed that PCOS is inherited. We are trying to look for clinical, blood and/or genetic markers of PCOS in the sisters and daughters of women with PCOS
- timeFrame
- age 8 until onset of menses
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 8 Years
- Maximum age
- 12 Years
Show eligibility criteria text
Inclusion Criteria: * Relatives with polycystic ovary syndrome * No relatives with polycystic ovary syndrome * Overweight * White non-hispanic girls Exclusion Criteria: * Chronic Illness * Smokers * Already having periods
References
Publications (1)
- BACKGROUNDUrbanek M, Sam S, Legro RS, Dunaif A. Identification of a polycystic ovary syndrome susceptibility variant in fibrillin-3 and association with a metabolic phenotype. J Clin Endocrinol Metab. 2007 Nov;92(11):4191-8. doi: 10.1210/jc.2007-0761. Epub 2007 Sep 4. PMID 17785364