Clinical trial · Interventional
A Study Of PF-03732010 In Patients With Advanced Solid Tumors
A Phase 1 Pharmacokinetic And Pharmacodynamic Study Of PF-03732010 In Patients With Advanced Solid Tumors
NCT00557505CI-TRIAL-00006595completedPhase 1Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
P-cadherin may play a part in tumor growth; PF-03732010 is a new drug that inhibits P-cadherin. This study will test how well the drug is tolerated, and what effects there might be. Blood will also be taken to measure the amount of drug in blood.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Neoplasms | Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| PF-03732010 | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- PF-03732010
- description
- Single Arm study
- interventionNames
- Drug: PF-03732010
Primary outcomes (2)
- measure
- Maximum Tolerated Dose (MTD)
- timeFrame
- Baseline up to end of treatment (EOT) or withdrawal assessed up to Day 7 of last cycle
- measure
- Recommended Phase-2 Dose (RP2D)
- timeFrame
- Baseline up to EOT or withdrawal assessed up to Day 7 of last cycle
Secondary outcomes (9)
- measure
- Area Under the Curve From Time Zero to Last Quantifiable Concentration [AUC (0-28 Day)]
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Advanced solid tumors refractory to (or intolerant of) established therapy known to provide clinical benefit, or for which there is no standard therapy * Age \>= 18 years of age * Adequate bone marrow function as defined by: absolute neutrophil count (ANC) ≥1500/uL, hemoglobin ≥ 9 g/dL, platelets \> 100,000/uL * Adequate liver function as defined by: bilirubin \< 1.5 x ULN, AST, ALT and ALP \< 2.5 x ULN, or \< 5 x ULN with documented liver and/or bone metastases * Serum creatinine \< 1.5 x ULN * ECOG status 0-1 * Availability of biopsy tumor tissue (or fine needle aspirate) for testing of P-cadherin expression * Tumor tissue (or fine needle aspirate) showing over-expression of P-cadherin * Must be able to give written informed consent * Be able to comply with scheduled study visits, treatment plans, laboratory tests and other procedures Exclusion Criteria: * Chemotherapy, radiotherapy, or any investigational cancer therapy within 4 weeks of study entry * Patients with carcinomatous meningitis or untreated brain metastases. * History of significant low platelet count, and/or bleeding disorders, requiring medical or surgical intervention * History of significant bleeding episodes within 6 months, unless the source of bleeding has been resected
References
Publications (0)
Data not yet available
No reference posted for this study.