Clinical trial · Interventional
Combined Photodynamic and Pulsed Dye Laser Treatment of Port Wine Stains
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research study was designed to determine the effect on port wine stains (PWS) of liposomal benzoporphyrin derivative monoacid (BPD-MA) termed verteporfin by intravenous (IV) infusion for photodynamic therapy (PDT) or combined PDT and pulsed dye laser (PDL) therapy (PDT + PDL). The standard treatment for PWS is PDL alone. This lightens some PWS but many lesions are not completely removed. PDT uses a medication and light together to cause injury to a target. The medication is given and then light is directed at the desired area of treatment to achieve an effect. PDT has been used to treat some skin conditions including pre-cancers and skin cancers. Using PDT or PDT immediately followed by PDL therapy may improve PWS lightening. At this time, both PDT and PDT + PDL therapy for treatment of PWS is investigational. The type and amount of medication and light which may be used to treat PWS is not known, and is likely to be different than those used for other PDT treatments.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Port Wine Stains | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Combined Photodynamic & Pulsed Dye Laser Treatment | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Combined Photodynamic & Pulsed Dye Laser Treatment
- description
- Treatment of Port Wine Stains
- interventionNames
- Drug: Combined Photodynamic & Pulsed Dye Laser Treatment
Primary outcomes (1)
- measure
- Blanching of Port Wine Stain Birthmark
- timeFrame
- 12 weeks
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult 18 years and older * Have a PWS on an area other than the face * A negative pregnancy test and non pregnant or nursing Exclusion Criteria: * Under 18 years of age * Have an allergy to verteporfin, porfimer sodium or other porphyrins * Have a history of porphyria (a disease that can cause sensitivity to light) * Have had treatment to the PWS test sites in the last 8 weeks * Have an active uncontrolled infection or other significant disease * Currently using medications that cause sensitivity to light such as tetracyclines, sulfonamides, phenothiazines, sulfonylurea hypoglycemic agents, thiazide diuretics and griseofulvin * Currently using medications that increase bleeding, including aspirin, coumadin or non-steroidal anti-inflammatory drugs * Have very dark skin which is sensitive to laser treatment * Have a positive ANA (lab tests which indicates sensitivity to light)
References
Publications (0)
Data not yet available