Clinical trial · Interventional
Intravenous Anesthesia Versus Anesthesia With Volatile Agents in Elective Craniotomy for Tumors
Effect of Total Intravenous Anesthesia Versus Anesthesia With Volatile Agents on Inflammatory Markers Following Elective Craniotomy for Primary Brain Tumor
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): PI decision to terminate. No usable data collected
Summary
Brief summary (as posted)
If the anesthetic regimen can influence the serum level of inflammatory cytokines and if the levels of cytokines are related to the incidence of post operative complications, these complications may be a function of the anesthetic method. In an effort to find the best anesthetic regimen for patients undergoing craniotomy for intracranial tumors, the researchers will compare the effect of volatile anesthetic with that of total intravenous anesthesia (TIVA) on cytokine levels. The researchers will also compare the composite incidence of some common major post-operative complications after craniotomy for intracranial malignancy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasms | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Propofol + Remifentanil | Drug | — | UNRESOLVED |
| Sevoflurane + Remifentanil | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Total Intravenous anesthetic
- description
- Intravenous anesthetics (propofol + remifentanil) for maintenance of General Anesthesia
- interventionNames
- Drug: Propofol + Remifentanil
- type
- ACTIVE_COMPARATOR
- label
- Volatile Anesthetic
- description
- Inhalational anesthetics (sevoflurane+remifentanil) for maintenance of General Anesthesia. Patients receive Sevoflurane as a volatile anesthetic and remifentanil as an IV agent for maintenance of general anesthesia.
- interventionNames
- Drug: Sevoflurane + Remifentanil
Primary outcomes (1)
- measure
- To study inflammatory changes associated with these two different anesthetic techniques
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients undergoing general anesthesia for elective surgical excision of a primary brain tumor * Age: Older than 18 * New and recurrent cases will be included Exclusion Criteria: * Patient refusal * Emergency craniotomy * Craniotomy after head injuries or intracranial bleeding * Patients with active inflammatory processes such as infection or immunologic illnesses known to increase baseline immunologic markers * Preoperative diagnosis of DVT by lower extremity ultrasound or symptoms * Preoperative pulmonary infiltrative disease (pulmonary fibrosis, sarcoid, etc.) * Pregnancy
References
Publications (0)
Data not yet available