Monotherapy Pazopanib in Subjects With Advanced Non-Small Cell Lung Cancer

Inclusion Criteria:

* Signed consent
* Histologically- or cytologically confirmed diagnosis of Stage IIIB or IV non-small cell lung cancer.
* Failed no more than two prior chemotherapy regimens for Stage IIIB or IV non-small cell lung cancer, including a platinum-containing regimen.
* Brain metastases permitted if subject has been treated with surgery and/or radiation therapy more than 4 weeks prior to date of first dose and is stable for at least one week off steroids.
* 18 years of age or older.
* Eastern Cooperative Oncology Group performance status of at least 2.
* Measurable disease according to RECIST.
* Adequate organ system function.
* Females may be eligible to enroll if they are of non-childbearing potential (surgically sterile or post-menopausal)or are using appropriate contraception methods.

Exclusion Criteria:

* Prior malignancy - unless disease-free for at least 3 years, or have had completely resected non-melanomatous skin cancer or successfully treated in situ carcinoma.
* History or clinical evidence of central nervous system metastases or leptomeningeal carcinomatosis, except for subjects with previously-treated CNS metastases, who are asymptomatic, and have had no requirement for steroids or anti-seizure medication for one week prior to first dose of study drug.
* Clinically significant gastrointestinal abnormalities.
* Presence of uncontrolled infection.
* Corrected QT interval greater than 480 msec.
* History of significant cardiovascular condition(s).
* Poorly controlled hypertension (systolic blood pressure of 140mmHG or greater or diastolic blood pressure of 90mmHg or greater).
* History of cerebrovascular accident, pulmonary embolism, or insufficiently treated deep venous thrombosis within the past 6 months prior to first dose of study drug.
* Major surgery or trauma within 28 days prior to first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer.
* Active bleeding or diathesis.
* Hemoptysis in excess of 2.5mL within 8 weeks of first dose of study drug.
* Serious and/or unstable pre-existing medical, psychiatric, or other condition that could interfere with subject's safety, provision of informed consent, or compliance with study procedures.
* Use of prohibited medications as defined in protocol.
* Use of an investigational agent, including an investigational anti-cancer agent within 28 days, or 5 half-lives, whichever is longer, prior to first dose of study drug.
* Prior use of any investigational or licensed anti-angiogenic agent, including thalidomide and agents that target platelet-derived growth factor. Prior treatment with bevacizumab or epidermal growth factor receptor tyrosine kinase inhibitors