Clinical trial · Interventional
Magnetic Resonance Elastography and 2-Point Dixon MR Imaging Techniques in Diffuse Liver Disease
Validation Study of Magnetic Resonance Elastography and 2-Point Dixon MR Imaging Techniques in Diffuse Liver Disease
NCT00543777CI-TRIAL-00051240completedPhase 1 / Phase 2Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical research study is to test the accuracy of magnetic resonance elastogram (MRE) and 2-point dixon magnetic resonance imaging (2PD MRI) using new computer software (called "phase correction algorithm") in patients who might have liver disease.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 2-Point Dixon Magnetic Resonance Imaging | Diagnostic Test | — | UNRESOLVED |
| Magnetic Resonance Elastogram | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- MRE + 2PD MRI
- description
- MRE - Pneumatic driver will be placed over the upper abdomen. Patient will feel a vibration (like a cell phone or beeper vibrating). This vibration will create very small waves in the body. The scanner will then receive the vibrations from the liver and use them to create images of the liver tissue. 2PD MRI - Imaging performed after the MRE procedure and lasting 20-60 seconds. This procedure is useful in identifying fat tissue.
- interventionNames
- Diagnostic Test: Magnetic Resonance Elastogram
- Diagnostic Test: 2-Point Dixon Magnetic Resonance Imaging
Primary outcomes (1)
- measure
- Overall Image Quality of Magnetic Resonance Elastography (MRE)
- timeFrame
- 2 Years
Secondary outcomes (2)
- measure
- Association Between Degrees of Stiffness Measured by MRE in kPa and Histopathological Grades of Fibrosis and Steatohepatitis
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. Group 1. Non-oncologic patients from VAMC in Houston: 2. Biopsy proven or clinically suspected advanced parenchymal liver disease 3. Core biopsies obtained within 1-month of MRI/MRE 4. No treatment affecting the status of liver between MRI/MRE and post-imaging biopsy 5. Signed consent 6. Group 2. Oncologic patients at MDACC: 7. Clinically or radiographically suspected liver damage, hepatic steatosis, hepatitis, hepatic fibrosis or cirrhosis 8. Surgical or core biopsy scheduled within 4 weeks of MRI/MRE 9. Signed consent Exclusion Criteria: 1. Claustrophobia 2. Contraindications for MRI 3. Unable to hold a breath 4. Ascites or other clinical or radiographical signs of portal hypertension
References
Publications (0)
Data not yet available
No reference posted for this study.