Clinical trial · Observational
Genetics of Women With Lobular Carcinoma in Situ of the Breast
GLACIER: A Study to Investigate the Genetics of LobulAr Carcinoma In Situ in EuRope
NCT00536718CI-TRIAL-00011686unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Gathering information about genetic changes in patients with lobular carcinoma in situ of the breast may help doctors learn more about the disease and find better methods of treatment. PURPOSE: This clinical trial is studying the genetics of women with lobular carcinoma in situ of the breast.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| gene expression analysis | Genetic | — | UNRESOLVED |
| medical chart review | Other | — | UNRESOLVED |
| molecular diagnostic method | Genetic | — | UNRESOLVED |
| polymorphism analysis | Genetic | — | UNRESOLVED |
| protein expression analysis | Genetic | — | UNRESOLVED |
| questionnaire administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Inherited variation predisposing development of lobular carcinoma in situ (LCIS) of the breast in women
- measure
- Frequency and effect of variants on tumor risk
- measure
- Clinical setting variant test value in identifying, counseling and screening those women at higher risk
Secondary outcomes (1)
- measure
- LCIS genetic changes which may progress to invasive cancer
Eligibility
Eligibility (as posted)
- Sex
- Female
- Maximum age
- 60 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS:
* Meets 1 of the following criteria:
* Current or prior diagnosis of lobular carcinoma in situ (LCIS) of the breast, including any of the following cases:
* Pure LCIS
* LCIS with subsequent development of invasive breast cancer of any morphological subtype
* LCIS presenting as an incidental finding together with invasive breast cancer of any morphological subtype
* Control participant matched for age and ethnicity to each LCIS patient
* Not affected by LCIS
* No history of ductal carcinoma in situ of the breast
* No breast cancer
* No relative (up to 2nd degree) who has been affected by breast cancer
* Male or female
PATIENT CHARACTERISTICS:
* Not specified
PRIOR CONCURRENT THERAPY:
* Not specifiedReferences
Publications (0)
Data not yet available
No reference posted for this study.