Clinical trial · Interventional
Morphine vs. Oxycodone for Postoperative Pain Management
Phase 4: A Comparison of Intravenous Administration of Morphine vs. Oxycodone for Postoperative Pain Management Following Laparoscopic Hysterectomy or Myomectomy
NCT00528177CI-TRIAL-00005166completedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether oxycodone provides better analgesia compared to morphine after laparoscopic hysterectomy or myomectomy.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hysterectomy | — | UNRESOLVED | — |
| Myoma | Myoma | ONTOLOGY_EXACT | 0.98 |
| Opioids | — | UNRESOLVED | — |
| Postoperative Pain | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Morphine and oxycodone | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- O
- description
- This arm will receive intravenous oxycodone at the end of surgery and PCA oxycodone for postoperative pain relief.
- interventionNames
- Drug: Morphine and oxycodone
- type
- ACTIVE_COMPARATOR
- label
- M
- description
- This arm will receive intravenous morphine at the end of surgery and PCA morphine for postoperative pain relief.
- interventionNames
- Drug: Morphine and oxycodone
Primary outcomes (1)
- measure
- Dosage relation between oxycodone and morphine. Pain score (VAS). Adverse effects.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Patients (American Society of Anaesthesiologists (ASA) I, II and III) due for elective, laparoscopic, non-malignant gynaecologic surgery: Hysterectomy or myomectomy. * Written informed consent. * Age: 18 to 70 years. Exclusion Criteria: * Patients having used non-steroidal anti-inflammatory drugs (NSAIDs) the last 24 hours. * Sensitivity towards the study drugs. * Cardiovascular risk conditions: Heart failure, unstable hypertension, coronary artery disease. * Patients using opioids, steroids or anti-emetic drugs. * Serious mental disease.
References
Publications (1)
- DERIVEDLenz H, Sandvik L, Qvigstad E, Bjerkelund CE, Raeder J. A comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy. Anesth Analg. 2009 Oct;109(4):1279-83. doi: 10.1213/ane.0b013e3181b0f0bb. PMID 19762758