A Safety Study of RTA 744 in Patients With Recurrent High-Grade Gliomas

Inclusion Criteria:

* Prior histologically confirmed anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic mixed oligo-astrocytoma, glioblastoma multiforme, or gliosarcoma, for whom no other effective therapy is available.
* A prior histologic diagnosis of a lower grade of glioma is allowed if there is current histologic proof of progression to a diagnosis of AA, AO, AOA, GBM or GS
* Unequivocal evidence of recurrence or progression by neuroimaging procedure.
* Surgical resection at least 2 weeks prior to enrollment and must have completely recovered from the side effects.
* A stable dose of steroids for at least 7 days prior to obtaining the Gd-MRI of the brain.
* Previously implanted Gliadel® wafer may be eligible.
* Karnofsky Performance Status (KPS) of ≥ 60.
* Laboratory parameters: Absolute Neutrophil Count (ANC) ≥ 1.5 x 109/L, Hemoglobin (Hgb) ≥ 9 g/dl, Platelets ≥ 100 x 109/L, AST and ALT ≤ 3.0 x Upper Limit of Normal (ULN), Serum bilirubin ≤ 1.5 x ULN, Serum creatinine ≤ 1.5 x ULN and 24 hour creatinine clearance ≥ 50 ml/min
* Life expectancy of greater than 12 weeks.
* Written informed consent obtained.

Exclusion Criteria:

* Pregnancy or breast feeding, or adults of reproductive potential not employing an effective method of birth control
* Total urinary protein in 24 hours urine collection \> 500 mg
* Any concurrent severe and/or uncontrolled medical conditions which could compromise participation in the study.
* Impaired cardiac function, other significant prior cardiac disease or arrhythmia of any
* A history of CHF or arrhythmias.
* Therapeutic doses of warfarin sodium (Coumadin®).
* Prior or concurrent therapy, or not recovered from the toxic effects of such therapy: investigational drugs, chemotherapy, metronomic daily dosing of chemotherapy agents, biologic, immunotherapy or cytostatic agents within 4 weeks prior to study entry; radiation therapy within 2 weeks prior to study entry, any medication known to cause QT interval prolongation
* Any surgery other than resection of a brain tumor within 2 weeks prior to enrollment.
* A contraindication to MRI imaging.