Clinical trial · Observational
Molecular Epidemiology of Therapy-related Acute Myeloid Leukemia/Myelodysplastic Syndrome (AML/MDS)
Molecular Epidemiology of Treatment-Related Acute Myeloid Leukemia/Myelodysplastic Syndrome
NCT00525746CI-TRIAL-00042757unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this research study is to identify biologic and lifestyle factors that may increase a person's risk of developing acute myeloid leukemia or myelodysplastic syndrome after treatment for a previous cancer (treatment-related AML/MDS).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Leukemia | Leukemia | ONTOLOGY_EXACT | 0.90 |
| Myelodysplastic Syndrome | Myelodysplastic Syndrome | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Interview | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Cases
- description
- Patients with a confirmed diagnosis of AML or MDS (cases).
- interventionNames
- Behavioral: Interview
- label
- Controls
- description
- Patients treated for a primary malignancy (controls).
- interventionNames
- Behavioral: Interview
Primary outcomes (1)
- measure
- Epidemiologic, Clinical, + Constitutional Markers Associated with t-AML/MDS Development
- timeFrame
- 3 Years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age 18 years or older 2. Willing and able to provide written informed consent and authorization 3. Willing to donate a saliva sample or 10 ml of blood and to complete a self-administered or personal interview 4. A histologically confirmed diagnosis of AML or MDS (cases only) 5. A history of a previous primary malignancy that was treated with chemotherapy and/or radiation therapy (cases only) 6. Enrolled in leukemia/MDS studies under protocol ID00-173 or ID03-0250 (cases only) 7. Treated for a primary malignancy at MDACC (controls only) 8. Matched to cases (2:1) by cases' prior malignancy(site, treatment (chemo and/or radiation), year of diagnosis (+/- 3 years)), age (+/- 5 years), sex, and ethnicity. (controls only) Exclusion Criteria: 1. Under 18 years of age 2. History of second primary malignancy (controls only)
References
Publications (0)
Data not yet available
No reference posted for this study.