PRelationship Between Physical Activity and Cancer Ris

This protocol is a sub-study of the ongoing "Protect Health and Reduce Cancer Risk" study conducted in Shanghai, China, and sponsored by the Shanghai Cancer Institute, Vanderbilt University, and the National Cancer Institute. The parent study is designed to examine the relationship of diet, lifestyle, occupational, and environmental risk factors, as well as genetic variation, to cancer incidence in a large cohort of men in women between 40 and 70 years of age. The current sub-study will assess the validity and reliability of a new physical activity questionnaire for use in the parent study and to evaluate whether different types of activity and the frequency, intensity, and duration of activity are associated with markers that have been linked to cancer risk, such as C-reactive protein, interleukin 6 and soluble tumor necrosis factor alpha. Participants in the current 12-month study are selected from among men and women participating in the "Protect Health and Reduce Cancer Risk" study. Participants keep a diary of their physical activity and complete two 30-minute interviews about their physical activity, one at the beginning and one at the end of the study period. Every 3 months for 7 consecutive days, they wear a pager-sized activity monitor on their waist that records their physical activity patterns during that period of time. They provide blood and urine samples four times during the study and, at the end of the study, undergo a health examination that includes an electrocardiogram, body composition measurement, and physical fitness test. The fitness test is a step-test consisting of 3-minute stages in which the subject successively increases the stepping speed until reaching 85 percent of his or her predicted maximal heart rate. Blood and urine samples are analyzed for levels of nutrients and certain proteins, and are stored for future studies related to nutrition and physical activity and possibly for genetic studies related to health, nutrition, exercise, or disease.

Sex

All

Minimum age

45 Years

Maximum age

75 Years

* INCLUSION CRITERIA:

The current study will be conducted in random sub samples of the Shanghai Women's Cohort Study and Shanghai Men's Cohort Study. Eligibility in these 2 cohort studies was determined based on the following: 40 to 70 years of age and residing in one of 7 Shanghai urban areas that is representative of all of urban Shanghai. Both women and men will be included in the study. No exclusions will be made by race, although it should be noted that the study population of the Shanghai Women's Cohort and Shanghai Men's Cohort Study is virtually 100% Asian.

EXCLUSION CRITERIA:

There wil be no prior from participation, other than the presence of physical ailments preventing subjects from participating in the study. Before participating in the fitness test, subjects will be screened for cardiovascular disease, othopedic limitations, or other factors that contraindicate testing, including pregnancy, respiratory problems at rest (labored breathing or persistent cough), presence of illness or fever, or swelling of the lower extremities. In addition, participants who do not adhere to the pre-test instructions of not eating heavily or drinking alcohol 2 hours before the test will be excluded from performing the fitness test.

Children will not be included in the current study, because study subjects are comprised of participants in the Shanghai Womens's Cohort Study and the Shanghai Men's Cohort Study, who are 40 to 70 years of age.

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• BACKGROUNDFriedenreich CM. Physical activity and cancer prevention: from observational to intervention research. Cancer Epidemiol Biomarkers Prev. 2001 Apr;10(4):287-301. PMID 11319168
• BACKGROUNDPopkin BM. The nutrition transition and obesity in the developing world. J Nutr. 2001 Mar;131(3):871S-873S. doi: 10.1093/jn/131.3.871S. PMID 11238777