Clinical trial · Observational
Unrelated Stem Cell Transplantation for Adults With Hematopoietic Disorders
Standard of Care Trial: Unrelated Stem Cell Transplantation for Adults With Hematopoietic Disorders
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study performs HLA matched stem cell transplantation from unrelated donors in adults who require stem cell transplantation but do not have a matched related donor available. The incidence of graft-versus-host disease in unrelated stem cell transplantation is recorded. This study also monitors the activity and toxicity of total body irradiation and cyclosphosphamide followed by stem cell transplantation from matched unrelated donors.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| ALL | Acute Lymphoblastic Leukemia | ALIAS | 0.90 |
| AML | Acute Myeloid Leukemia | CURATED_BROADER | 0.80 |
| CML | Chronic Myeloid Leukemia, BCR-ABL1 Positive | ALIAS | 0.90 |
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
| Myelodysplasia | Myelodysplastic Syndrome | ALIAS | 0.90 |
| Myeloproliferative Disorders | Myeloproliferative Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 16 Years
- Maximum age
- 54 Years
Show eligibility criteria text
Inclusion Criteria: * Age \>15 and \<55 * Adequate renal function with serum creatinine \<2.0 mg/dl * Pulmonary diffusing capacity\>50% of predicted * Cardiac ejection fraction \>40% as measured by radionuclide wall motion study or echocardiography * Total bilirubin must be \<2.5 mg/dl. * Alkaline phosphatase and AST must be less than three times the upper limit of normal * Negative serology for the human immunodeficiency virus * Available HLA-matched donor * Signed informed consent Exclusion Criteria: * No fully or single-antigen-mismatched sibling donor is available to donate stem cells * No active liver disease.
References
Publications (0)
Data not yet available