Clinical trial · Observational
Intensity Modulated Radiotherapy (IMRT) for the Pelvis Post-Hysterectomy
Pilot Study of Intensity Modulated Radiotherapy (IMRT) to Pelvis Post-Hysterectomy With Analysis of Clinical Target Volume Motion and Relation to Position and Volume of Bladder and Rectum During Course of Radiotherapy for Use in Optimization of Margin Size
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical research study is to use CT scans to find any changes in position of the vagina and pelvic lymph node areas during the course of IMRT radiation therapy. Treatment can then be adjusted in order to "spare" as much normal tissue as possible during radiation therapy. Another goal is to study the side effects of IMRT radiation therapy.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
| Endometrial Cancer | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
| Uterine Cancer | Malignant Uterine Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CT Scan | Procedure | — | UNRESOLVED |
| Intensity Modulated Radiotherapy (IMRT) | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- CT Scan + IMRT Radiation Therapy
- interventionNames
- Radiation: Intensity Modulated Radiotherapy (IMRT)
- Procedure: CT Scan
Primary outcomes (1)
- measure
- Maximum variations in position of the vagina and lymph node regions caused by bladder filling and emptying
- timeFrame
- 2 Years (every 3 months for first year and 4 months for second year)
Secondary outcomes (1)
- measure
- Day-to-day variations in position of vaginal vault and pelvic lymph node regions
- timeFrame
- During a 5-week course of intensity modulated pelvic radiation therapy
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: 1. Patients who have been treated with a hysterectomy for carcinoma of the uterine cervix or endometrium who require post-operative radiation or chemoradiation therapy because of positive pelvic lymph nodes or other high-risk local findings. 2. Patients must have no evidence of metastatic disease outside of the pelvis. 3. Patients must have a Karnofsky Performance Status of \>60. 4. The patient must be able to understand the protocol and sign a study-specific informed consent. . Exclusion Criteria: 1. Karnofsky Performance Status \< 60. 2. Patients with para-aortic nodal disease or who require extended field radiotherapy beyond the pelvis. 3. Obese patients who exceed the size limits of hte treatment table or CT scanner. 4. Mental status changes or bladder control problems that make the patient unable to comply with bladder-filling instructions.
References
Publications (0)
Data not yet available