Clinical trial · Interventional
Tracking of Respiratory-Induced Tumor Motion Using Implanted Fiducials
Assessment of the Reliability of Implanted Fiducials for Tracking of Respiratory-Induced Tumor Motion
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Objectives: * To determine the safety of fiducial implantation. * To determine the extent/rate of migration of radio-opaque fiducials placed in lung tumors and adjacent normal tissue. * To compare real-time portal imaging-based fiducial tracking with measurement of three-dimensional motion by four-dimensional CT scanning to determine how many fiducials are needed to track a tumor. * To determine if intra-fractional lung tumor motion changes during a course of treatment, and when during the treatment this occurs. * To correlate the position of internal fiducials with the position of the external patient surface during respiration. * To quantify the residual motion of the clinical target volume during radiotherapy gated using external fiducials. * To verify the adequacy of the treatment portal margins in encompassing the residual motion of the clinical target volume. * To determine if radio-opaque fiducial placement adjacent to the trachea (which does not move) can reduce daily setup inaccuracies, and so spare normal tissue. * To determine the motion of hilar adenopathy (if any), and whether it correlates with motion of the primary tumor.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CT Scans | Procedure | — | UNRESOLVED |
| Implanted markers | Procedure | — | UNRESOLVED |
| Radiation Treatment (RT) | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Implanted Markers + CT + RT
- interventionNames
- Procedure: CT Scans
- Procedure: Implanted markers
- Radiation: Radiation Treatment (RT)
Primary outcomes (1)
- measure
- Number of patients experiencing motion of one or more fiducials during the course of radiation therapy
- timeFrame
- Baseline, 6 weeks
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. Patient must be undergoing radiation treatment. 2. Planned course of radiation treatment must be greater than or equal to 6 weeks. 3. The patient is able to tolerate bronchoscopy: a. Able to maintain oxygen saturation \>95% on room air nasal cannula supplementation \<5L/min, b. Can tolerate supine position without respiratory difficulties, c. Has normal hemodynamic parameters, d. Has normal coagulation profile 4. The patient is a candidate for bronchogenic placement of seeds. 5. The patient has an identifiable tumor on a CT scan. 6. The patient has signed the consent form. Exclusion Criteria: 1. The patient has had previous thoracic surgery (e.g., lobectomy, pneumonectomy, tumor excision). Biopsy, mediastinoscopy, mastectomy are not exclusions. 2. The patient has had previous radiation to the thorax.
References
Publications (0)
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