Clinical trial · Interventional
Proton Beam Therapy for Chondrosarcoma
Phase II Evaluation of Proton Beam Therapy for Skull Base Chondrosarcoma
NCT00496522CI-TRIAL-00104970active not recruitingPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 30, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260930-000001
Summary
Brief summary (as posted)
The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chondrosarcoma. The safety of this treatment will also be studied.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chondrosarcoma | Chondrosarcoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Proton Beam Therapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Proton Beam Therapy
- description
- Proton Beam Therapy - A total dose of up to 70 CGE given at 2.0 CGE per daily fraction for 35 fractions.
- interventionNames
- Procedure: Proton Beam Therapy
Primary outcomes (1)
- measure
- Time to Local Recurrence
- timeFrame
- Baseline to local recurrence (evaluation every six months during estimated 5 year study)
- description
- Local recurrence defined as progression on magnetic resonance imaging (MRI) or CT if MRI is contraindicated.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. Pathologically confirmed Grade 1-3 chondrosarcoma of the skull base 2. Contrast enhanced postop MRI or CT if there is clinical contraindication for MRI of the skull base obtained with 90 days of study registration at M. D. Anderson 3. The patient has been assessed by MDACC skull base surgeons to have undergone maximal surgical debulking of disease 4. Karnofsky Performance status greater than or equal to 60 5. Signed informed consent Exclusion Criteria: 1. Previous irradiation of the skull base 2. Documented evidence of disseminated metastatic disease
References
Publications (0)
Data not yet available
No reference posted for this study.