Clinical trial · Observational
Study of Insulin Resistance and Endometrial Cancer in Harris County, Texas
Case-Control Study of Insulin Resistance and Endometrial Cancer in Harris County, Texas
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical research study is to find out if there is a link between insulin resistance (or pre-diabetes) and endometrial cancer. Primary Objective: 1\. To determine the association between insulin resistance and endometrial cancer in women in Harris County, Texas. 2. To assess the effect of body mass index (BMI) on the association between insulin resistance and endometrial cancer. Secondary Objectives: 1. To explore the association between polycystic ovarian syndrome (PCOS) and endometrial cancer. 2. To assess the relationship between known reproductive risk factors, menstrual risk factors, family history and endometrial cancer. 3. To explore the molecular changes associated with insulin resistance and PCOS on normal endometrium and tumor tissue.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Endometrial Cancer | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Questionnaire | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Endometrial Cancer Group
- description
- Participants who have had endometrial cancer (cases).
- interventionNames
- Behavioral: Questionnaire
- label
- Control Group
- description
- Participants who have not had endometrial cancer (controls).
- interventionNames
- Behavioral: Questionnaire
Primary outcomes (1)
- measure
- Prevalence Rate of Insulin Resistance
- timeFrame
- 5 Years
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: 1. Women with histologically confirmed primary endometrial cancer, who will consent to be enrolled in the study no later than 12 weeks after their primary treatment. All stages, grades and histologic subtypes will be eligible. 2. Women who reside in Harris County, Texas. (Cases) 3. Patients must sign an informed consent for the study. (Cases) 4. Women must speak and understand English or Spanish. (Cases) 5. Women who reside in Harris County, Texas. (Controls) 6. No history of prior malignancy with the exception of non-melanoma skin cancer. (Controls) 7. Intact uterus. (Controls) 8. Patients must sign an informed consent for the study. (Controls) 9. Women must speak and understand English or Spanish. (Controls) Exclusion Criteria: 1. Women who reside outside of Harris County, Texas. (Cases) 2. Patients unwilling or unable to provide informed consent. (Cases) 3. Metastatic cancer to the endometrium from a different primary. (Cases) 4. Women who do not speak and understand English or Spanish. (Cases) 5. Women who reside outside of Harris County, Texas. (Controls) 6. Previous hysterectomy. (Controls) 7. History of prior malignancy with the exception of non-melanoma skin cancer. (Controls) 8. Patients unwilling or unable to provide informed consent. (Controls) 9. Women who do not speak and understand English or Spanish. (Controls)
References
Publications (0)
Data not yet available