Clinical trial · Interventional
H-9926-LCH III: Treatment Protocol of the Third International Study for Langerhans Cell Histiocytosis
NCT00488605CI-TRIAL-00068489withdrawnPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): This is a duplicate record and the sponsor has registered the study.
Summary
Brief summary (as posted)
LCH III is an international, multicentric, prospective clinical study comprised of: * a randomized clinical trial for multisystem "RISK" patients and * a randomized clinical trial for multisystem "LOW RISK" patients and * a pilot study for patients with single system MFB and localized "SPECIAL SITES"
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Leukemia | Leukemia | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Leucovorin, Methotrexate, Vinblastine, Prednisone | Drug | — | UNRESOLVED |
| Prednisone, Vinblastin, 6-mercaptopuroine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Treatment Arm A
- interventionNames
- Drug: Prednisone, Vinblastin, 6-mercaptopuroine
- type
- EXPERIMENTAL
- label
- Treatment Arm B
- interventionNames
- Drug: Leucovorin, Methotrexate, Vinblastine, Prednisone
Primary outcomes (1)
- measure
- The proportion of non-responder in risk organs to the initial treatment
- timeFrame
- 12 months
Secondary outcomes (5)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: All newly diagnosed patients who meet the following criteria are eligible to be enrolled and followed in the study: * Definitive diagnosis of LCH * Age under 18 years * No prior treatment for LCH Exclusion Criteria: * Not specified
References
Publications (0)
Data not yet available
No reference posted for this study.