Dendritic Cell Vaccine for High Risk Ovarian Cancer Patients

Inclusion Criteria:

* The following conditions must be met before a patient may be enrolled in the study.
* Patients age 18 years of age and older.

Disease Criteria. Patients will be eligible:

* If no clinical evidence of disease is present after diagnosis with stage III or
* IV disease and completion of primary surgery and chemotherapy, or, if no clinical evidence of disease is present after completion of chemotherapy for a disease recurrence diagnosed after a progression-free interval of at least 2 years, for patients of any initial stage.or primary peritoneal carcinoma.
* Complete clinical response = no evidence of tumor lesions shown by abdominal CT scan or MRI, chest Xray,and CA 125 level ≤ 35 UI/mL.
* Time from completion of Chemotherapy will be no more than 6 months from last dose from initial diagnoses.
* HLA-A2 positive (must be typed by molecular methods; all A2 alleles eligible).

Patients with adequate organ function as measured by:

* Hematopoietic: WBC at least 3000/mm3; platelets at least 100,000/mm3, hemoglobin at least 10.0 g/dL (may be transfused).
* Cardiac: Asymptomatic or, if symptomatic, then left ventricular ejection fraction at rest must be ≥50% or within the normal range of the institution. A cardiology clearance will be required for LV ejection fraction \<50%.
* Hepatic: SGOT within 2x normal range and total bilirubin ≤ 2.0 mg/dL.
* Renal: Serum creatinine ≤2.0 mg/dL
* Adequate performance status \> 80% (Karnofsky) or ECOG 0-2
* Written informed consent conforming to institutional guidelines.
* Life expectancy \> 6 months and absence of co-existing medical problems which would preclude participation in the judgment of the principal investigator.

Exclusion Criteria:

* Any one of the following conditions eliminates a patient from participating in this protocol.
* Prior malignancy (except basal cell or squamous cell skin cancer) within the past five years.
* Presence of active Central Nervous System disease.
* Serious systemic disease.
* Active bacterial, viral or fungal infections.
* Chemotherapy, biologic therapy or radiation therapy less than 4 weeks prior to study entry.
* History of active autoimmunity or immunosuppression.
* Use of immunosuppressive drugs within 4 weeks prior to study entry or anticipated use of immunosuppressive agents.
* Patients with tumors of low malignant potential (borderline tumors) will not be eligible.
* Seropositivity for HIV, HTLV-1, or HTLV-2.
* Prior Influenza vaccination with the current vaccine will exclude patient from receiving protocol-specified influenza vaccine but will not exclude participation with the other aspects of the protocol. Each year's vaccine supply generally becomes available in October. Patients with a history of serious hypersensitivity to eggs, previous influenza vaccine or its components, will not receive influenza vaccine, but may continue to participate in other aspects of the protocol. Patients with a history of serious hypersensitivity to the Prevnar vaccine, its components, or diptheria toxoid will not receive the Prevnar vaccine, but may continue to participate in other aspects of the protocol.
* Pregnant or breast feeding subjects.