Clinical trial · Interventional
A Study of Loading Doses of Intravenous Bondronat (Ibandronate) in Patients With Breast Cancer and Metastatic Bone Disease.
An Open Label Study to Assess the Effect of Intravenous Loading Doses of Bondronat on Metastatic Bone Pain in Patients With Breast Cancer and Skeletal Metastases.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This single arm study will assess the efficacy of loading doses of intravenous Bondronat in reducing pain in patients with breast cancer and metastatic bone disease experiencing moderate to severe bone pain. Patients will receive an intravenous infusion of 6mg Bondronat on days 1, 2 and 3. The anticipated time on study treatment is \<3 months, and the target sample size is \<100 individuals.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bone Neoplasm | Bone Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Neoplasm Metastasis | — | UNRESOLVED | — |
| Pain | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ibandronate [Bondronat] | Drug | Ibandronic Acid | ALIAS |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- 1
- interventionNames
- Drug: ibandronate [Bondronat]
Primary outcomes (1)
- measure
- Pain response (20% decrease in mean pain score compared to baseline, and <=50% increase in mean analgesic consumption
- timeFrame
- Days 5 - 7
Secondary outcomes (4)
- measure
- Mean worst pain score over first 7 days
- timeFrame
- Day 7
- measure
- Analgesic consumption
- timeFrame
- Day 7
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * adult patients, \>=18 years of age; * breast cancer; * bone metastases; * mean worst pain score \>=4 during 3 day baseline period; * stable dose of analgesics over a 3 day baseline period; * adequate renal function. Exclusion Criteria: * bisphosphonate treatment within 3 weeks of study enrollment; * a change in antineoplastic treatment within 6 weeks of study enrollment; * bone radiation within 2 weeks of study enrollment; * active infection.
References
Publications (0)
Data not yet available