Clinical trial · Interventional
Opioid Rotation Versus Combination for Chronic Uncontrolled Cancer Pain
NCT00478101CI-TRIAL-00001342completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
For cancer patients with inadequate pain relief, a switch to an alternative opioid is the preferred option for symptomatic improvement. However, multiple opioids are often simultaneously administered for anecdotal reasons. The present study isdesigned to assess the analgesic profiles of two different strategies in chronic cancer pain: the opioid rotation from oxycodone to transdermal fentanyl and the combination of oral oxycodone and transdermal fentanyl.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Solid Cancers | Malignant Solid Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| oxycodone fentanyl | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Change in pain score and treatment success
Secondary outcomes (1)
- measure
- Patient satisfaction
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: * Chronic Uncontrolled Pain That Required Stronger Opioid Therapy Than They Have Been Taking * Histologically Confirmed Solid Cancer * Aged Over 18 Years * Admitted in a Palliative Cancer Care Unit Exclusion Criteria: * Uspected to Have Narcotic Abuse, Clinically Relevant CO2 Retention or Had an Active Skin Disease * Inability to swallow oral medication, and impaired sensory or cognitive function * Patients who had an active infection, uncontrolled central nervous system involvement, or on antitumor therapy of any kind
References
Publications (1)
- DERIVEDKim HJ, Kim YS, Park SH. Opioid rotation versus combination for cancer patients with chronic uncontrolled pain: a randomized study. BMC Palliat Care. 2015 Sep 16;14:41. doi: 10.1186/s12904-015-0038-7. PMID 26377913