Angiotensin-(1-7) in Treating Patients With Metastatic or Unresectable Solid Tumors

DISEASE CHARACTERISTICS:

* Histologically or cytologically confirmed advanced solid tumor meeting 1 of the following criteria:

  * Metastatic disease
  * Unresectable disease
* Standard curative or palliative measures do not exist or are no longer effective
* Measurable or nonmeasurable disease

  * Measurable disease, defined as ≥ 1 unidimensionally measurable lesion ≥ 20 mm by conventional techniques or ≥ 10 mm by spiral CT scan
  * Nonmeasurable disease, defined as all other lesions, including small lesions (i.e., ≥ 1 unidimensionally measurable lesion \< 20 mm by conventional techniques or \< 10 mm by spiral CT scan) and truly nonmeasurable lesions, including any of the following:

    * Bone lesions
    * Ascites
    * Pleural or pericardial effusion
    * Lymphangitis cutis or pulmonis
    * Abdominal masses not confirmed and followed by imaging techniques
    * Cystic lesions
* No lung cancer with recent hemoptysis
* No brain metastasis

PATIENT CHARACTERISTICS:

* ECOG performance status 0-2
* Life expectancy \> 4 weeks
* No evidence of bleeding diathesis
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception
* Granulocyte count ≥ 1,500/mm³
* Platelet count ≥ 100,000/mm³
* Creatinine clearance \> 30 mL/min
* Bilirubin \< 2 mg/dL
* AST and ALT \< 3 times upper limit of normal
* No concurrent uncontrolled illness including, but not limited to, any of the following:

  * Ongoing or active infection
  * Symptomatic congestive heart failure
  * Unstable angina pectoris
  * Cardiac arrhythmia
  * Uncontrolled hypertension or hypotension
* No psychiatric illness or social situation that would preclude informed consent or study compliance

PRIOR CONCURRENT THERAPY:

* At least 4 weeks since prior major surgery
* At least 4 weeks since prior radiotherapy or chemotherapy (6 weeks for melphalan, nitrosoureas, or mitomycin C)
* No concurrent therapeutic anticoagulation
* No other concurrent investigational agents
* No concurrent angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers
* No concurrent combination antiretroviral therapy for HIV-positive patients