Clinical trial · Interventional
Effect of Daily Calorie or Alternate-day Calorie Reductions on Risk for Cardiovascular Disease and Cancer
Effect of Daily Calorie Restriction or Alternate-day Reductions in Calorie Intake on Risk for Cardiovascular Disease and Cancer
NCT00467220CI-TRIAL-000429261072completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to examine and compare the effects of alternate-day reductions in calorie intake or daily calorie restriction on the risk for cardiovascular disease and cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Moderately Overweight Individuals | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| calorie restriction | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- NO_INTERVENTION
- label
- Control
- description
- Subjects will follow all study tasks but will not be required to follow a calorie-restricted meal plan.
- type
- OTHER
- label
- Alternate Day Fasting Arm
- description
- Subjects in this arm will be asked to alternate between one day of eating as they wish versus one day on a calorie-restricted meal plan. Subjects will follow this alternating meal plan for 3 months.
- interventionNames
- Behavioral: calorie restriction
- type
- OTHER
- label
- Calorie Restriction
- description
- Subjects in this arm will be asked to follow a calorie-restricted meal plan, daily, for three months.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 35 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Male and female; body mass index (BMI) between 20-30 kg/m2; * Age between 35-65 years; sedentary (light exercise less than 1h per week) or moderately active (1 to 2h per week); * Weight stable for \>3 months prior to the beginning of the study; * Able to give written informed consent; * Female subjects must be post-menopausal for at least 2 years and can not be on hormone replacement therapy (HRT). Exclusion Criteria: * Diabetic; * History of cardiovascular disease, i.e. myocardial infarction or stroke; * History of cancer; * Taking glucose lowering medication; * Taking weight loss medication
References
Publications (1)
- DERIVEDAllaf M, Elghazaly H, Mohamed OG, Fareen MFK, Zaman S, Salmasi AM, Tsilidis K, Dehghan A. Intermittent fasting for the prevention of cardiovascular disease. Cochrane Database Syst Rev. 2021 Jan 29;1(1):CD013496. doi: 10.1002/14651858.CD013496.pub2. PMID 33512717