Sorafenib Tosylate and Gene Expression Analysis in Patients Undergoing Surgery For High-Risk Localized Prostate Cancer

Inclusion Criteria:

* Histologically confirmed adenocarcinoma of the prostate
* Radical prostatectomy and lymph node dissection planned as primary therapy in a patient with acceptable surgical risk (e.g., cardiovascular, pulmonary, and functional status)
* 10 year or longer life expectancy
* Any of the following high-risk features: Clinical stage T2b (palpable bilateral involvement) OR surgically resectable T3 OR PSA \>= 20 ng/ml OR overall Gleason grade \>= 8
* No evidence of bone metastases on bone scan
* No evidence of lymph nodes \>= 2 cm in diameter on pelvic CT scan
* Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
* Hemoglobin \>= 9.0 g/dl
* Absolute neutrophil count (ANC) \>= 1,500/mm\^3
* Platelet count \>= 100,000/mm\^3
* Total bilirubin =\< 1.5 x ULN
* ALT =\< 2.5 x the ULN
* AST =\< 2.5 x the ULN
* INR =\< 1.5 and aPTT within normal limits
* Creatinine =\< 1.5 x ULN or creatinine clearance \> 60mL/min/1.73 m\^2
* Men must agree to use adequate contraception (abstinence, hormonal in female partner, or barrier method of birth control) prior to study entry, for the duration of study participation, and for at least two weeks after stopping treatment
* Signed informed patient consent

Exclusion Criteria:

* Prior therapy for prostate cancer including conventional androgen deprivation therapy, radiotherapy (external beam or brachytherapy), cryotherapy, and/or cytotoxic chemotherapy
* Any known metastasis; patients with neurological symptoms must undergo a CT scan/MRI of the brain to exclude brain metastasis
* Significant active medical illness which in the opinion of the investigator would preclude protocol treatment
* Another malignancy, other than non-melanoma skin cancer, during the past 5 years
* History of bleeding diathesis or unexpected surgical bleeding
* Patients with active coagulopathy
* Cardiac disease: Congestive heart failure \> class II NYHA; patients must not have unstable angina (anginal symptoms at rest) or new onset angina (began within the last 3 months) or myocardial infarction within the past 6 months
* Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy
* Uncontrolled hypertension, as defined by systolic blood pressure consistently in excess of 150 mmHg, or diastolic pressure consistently in excess of 90 mmHg
* Thrombolic or embolic events such as a cerebrovascular accident including transient ischemic attacks within the past 6 months
* Pulmonary hemorrhage/bleeding event \>= CTCAE Grade 2 within 4 weeks of first dose of study drug
* Any other hemorrhage/bleeding event \>= CTCAE Grade 3 within 4 weeks of first dose of study drug
* History of allergic reactions attributed to compounds of similar chemical or biologic composition to sorafenib
* Patients may not be concurrently receiving any chemotherapy, immunotherapy, hormonal therapy, or molecular targeted agents to treat their prostate cancer
* Patients may not be receiving any other investigational agents
* Therapeutic anticoagulation with heparin, low-molecular weight heparin, or warfarin within the last 4 weeks
* Patients may not be using rifampin, digoxin, quinidine, ketoconazole, itraconazole, cyclosporine, carbamazepine, phenytoin, phenobarbital, St. John's Wart, or products containing grapefruit juice
* Patients may not be using bevacizumab or any other drugs that target VEGF or VEGF receptors
* Active clinically significant infections (\>= grade 2 NCI-CTCAE version 3.0); patients may enroll after infection resolves
* HIV-positive patients receiving combination anti-retroviral therapy because of possible pharmacokinetic interactions with Sorafenib
* Any condition that impairs patient's ability to swallow whole pills
* Any malabsorption problem