Clinical trial · Interventional
High-dose Bevacizumab in Advanced Renal Carcinoma Patients
Phase II Trial of High-Dose Bevacizumab in the Treatment of Patients With Advanced Clear Cell Renal Carcinoma
NCT00455975CI-TRIAL-00016409completedPhase 2Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial will examine the effectiveness and the side effects of 2 higher dosing schedules of bevacizumab in patients that have advanced clear cell renal carcinoma.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Kidney Cancer | Malignant Kidney Neoplasm | CURATED_EXACT | 0.92 |
| Renal Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bevacizumab | Drug | Bevacizumab | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Weekly Avastin
- description
- Bevacizumab 15mg/kg IV weekly until progressive disease or toxicity
- interventionNames
- Drug: Bevacizumab
- type
- EXPERIMENTAL
- label
- Bi-weekly Avastin
- description
- Bevacizumab 15mg/kg IV every 2 weeks until progressive disease or toxicity
- interventionNames
- Drug: Bevacizumab
Primary outcomes (1)
- measure
- Progression-free Survival
- timeFrame
- 18 months (expected)
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically documented metastatic or unresectable locally recurrent clear cell renal carcinoma * Previous kidney removal is required except if the primary tumor was smaller than 5 cm or there was extensive liver or bone metastasis * Patients may have received a maximum of 1 prior systemic treatment of immunotherapy (Interferon, IL-2), chemotherapy, or combination chemo+immunotherapy for metastatic disease. * No prior bevacizumab * Measurable disease * Adequate liver and kidney function * Age 18 and older Exclusion Criteria: * Acute MI within the past 6 months * Uncontrolled high blood pressure or history of hypertensive crisis * Clinically significant cardiovascular disease * Active brain cancer * Meningeal metastasis * Pregnant or lactating women * Prior treatment for another cancer less than 5 years ago * No diseases of the central nervous system (eg. uncontrolled seizures, strokes or TIAs * No bleeding from the mouth, rectum or coughing up blood or history of other bleeding or clotting disorders * No history of deep vein thrombosis less than 12 months ago or are currently requiring full dose anticoagulation * No major surgical procedures, open biopsies or traumatic injury in past 28 days * No patients with peg tubes or feeding tubes * No patients with non healing wounds, ulcers or long bone fractures * No history of abdominal fistulas, gastrointestinal perforation or intrabdominal abscess within 6 months * No symptomatic peripheral vascular disease Please note: there are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have. You can then decide if you wish to participate.
References
Publications (0)
Data not yet available
No reference posted for this study.