Clinical trial · Observational
Identifying Gene Mutations in Patients With Melanoma and in Families With a History of Hereditary Melanoma
Studies of Familial Melanoma
NCT00450593CI-TRIAL-00011714unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Identifying gene mutations and other risk factors in patients with melanoma and in families with a history of hereditary melanoma may help doctors identify persons at risk for melanoma and other types of cancer. It may also help the study of cancer in the future. PURPOSE: This clinical trial is studying gene mutations in patients with melanoma and in families with a history of hereditary melanoma.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hereditary Multiple Melanoma | — | UNRESOLVED | — |
| Melanoma (Skin) | Melanoma | ONTOLOGY_EXACT | 0.85 |
Interventions
Interventions (7)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| gene expression analysis | Genetic | — | UNRESOLVED |
| laboratory biomarker analysis | Other | — | UNRESOLVED |
| microarray analysis | Genetic | — | UNRESOLVED |
| molecular genetic technique | Genetic | — | UNRESOLVED |
| mutation analysis | Genetic | — | UNRESOLVED |
| mutation carrier screening | Procedure | — | UNRESOLVED |
| study of high risk factors | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (4)
- measure
- Predictive significance of melanoma susceptibility gene (MSG) mutations in the CDKN2A gene
- measure
- Susceptibility to other types of cancer as a feature of MSG mutations
- measure
- Risk of other types of cancers in mutation carriers
- measure
- Environmental exposures, in particular sun exposure, that modify risk of melanoma in MSG mutation carriers
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
DISEASE CHARACTERISTICS:
* Meets one of the following criteria:
* Prior multiple primary melanomas
* Histological samples available
* Family history of melanoma, with melanoma in two first-degree relatives (e.g., cases of melanoma in both a mother and son or in two brothers but not in two cousins)
* Family history of melanoma, where three or more individuals (of any relationship) have had melanoma
PATIENT CHARACTERISTICS:
* Not specified
PRIOR CONCURRENT THERAPY:
* Not specifiedReferences
Publications (0)
Data not yet available
No reference posted for this study.