Safety Study of TroVax Alone vs. TroVax Plus Interferon Alpha in Patients With Renal Cancer

Inclusion Criteria:

* Locally advanced or metastatic histologically confirmed clear cell or papillary cell renal carcinoma.
* Primary tumor surgically removed.
* Stable or progressive disease as defined by RECIST criteria.
* Age ≥ 18 years.
* At least one prior standard of care therapy (IL-2, IFN-α, or approved kinase inhibitor)
* At least four weeks from prior use of standard of care therapy.
* Karnofsky performance status ≥ 80%.
* Corrected Serum Calcium ≥ 10 g/dL.
* Patients on stable doses of bisphosphonates (Fosamax, Actonel, Didrocal) that show subsequent tumor progression may continue on this medication; however patients are not allowed to start bisphosphonates within one month prior to starting trial, or throughout the duration of the trial.
* Major surgery or radiation therapy completed ≥ 4 weeks prior to treatment.
* Clinically immunocompetent.
* Free of clinically apparent autoimmune disease.
* Absolute lymphocyte count ≥ 500/μL, Absolute neutrophil count ≥ 1200/μL, Platelet count ≥ 100,000/μl, Hemoglobin ≥ 9mg/dL.
* No evidence of active ischemia on Electrocardiogram (ECG)
* Women must be either post-menopausal, rendered surgically sterile, or using reliable form of contraceptive.
* Able to give informed consent and comply with the protocol.

Exclusion Criteria:

* Prior treatment with TroVax®
* No supplements of complementary medicines/botanicals are permitted during study, except for any combination of the following: multivitamins, selenium, lycopene, soy supplements, Vitamin E.
* Prior radiopharmaceuticals (strontium, samarium) within 8 weeks prior to enrollment.
* Participation in any other clinical trial within 30 days.
* Cerebral metastasis on MRI Scan.
* Currently active second malignancy, other than non-melanoma skin cancer. Patients are not considered to have a "currently active" malignancy if they have completed therapy and are considered by their physician to be at least less than 30% risk of relapse.
* Serious intercurrent infections or nonmalignant medical illnesses which are uncontrolled.
* Psychiatric illnesses that would limit compliance with protocol.
* A history of psychosis or clinical depression.
* Liver function tests (ALT, AST) more than 1.5 X upper limit of normal (ULN). Bilirubin must be within normal limits.
* Creatinine ≥ 1.5 X ULN.
* Known allergy to egg proteins.
* Known allergy to neomycin.
* History of allergic response to previous vaccinia vaccinations.
* Chronic oral corticosteroid use unless prescribed as replacement therapy in the case of adrenal insufficiency.
* Positive for HIV or Hepatitis B or C.
* Clinical indication of reduced cardiac function or an ejection fraction of ≤ 40%.
* Pregnancy or lactation
* Current chemotherapy, immunotherapy, radiation therapy, or the requirement for radiotherapy.
* No investigational or commercial agents or therapies other that those included in the protocol treatment may be administered with the intent to treat malignancy.