Clinical trial · Interventional
Pharmacological Modulation of the Intrarenal Pressure During Endourological Procedures in the Upper Urinary Tract
NCT00428428CI-TRIAL-00000981completedPhase 2 / Phase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of the study is to examine the effect of endoluminally administrated isoproterenol on pelvic pressure increase during flexible ureterorenoscopy in 14 humans. We propose that isoproterenol has potential of reducing intrarenal pressure during ureterorenoscopies. Lower intrarenal pressures may have the advantage of facilitating the procedure and reducing intraoperative complications as bleeding and infections.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Benignant Tumour Mass in the Upper Urinary Tract | — | UNRESOLVED | — |
| Kidney Stone | — | UNRESOLVED | — |
| Unexplained Haematuria | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Isoproterenol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- 1
- description
- Saline irrigation
- interventionNames
- Drug: Isoproterenol
- type
- ACTIVE_COMPARATOR
- label
- 2
- description
- ISO irrigation
- interventionNames
- Drug: Isoproterenol
Primary outcomes (1)
- measure
- pelvic pressure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Indication for ureterorenoscopy * Age\> 18 years * Normal blood pressure Exclusion Criteria: * Malignant disease in the upper urinary tract * Heart disease * Allergy to Isoproterenol * Use of α-blocking or β-blocking medicine * Use of Calcium-antagonists * Use of NSAIDs the last 48 hours * Present stone or JJ-stent in the ureter * Neurologic disease in the bladder * Pregnancy * Nursing mothers
References
Publications (0)
Data not yet available
No reference posted for this study.