Clinical trial · Interventional
Nicotine in Treating "Hunger Pain" in Patients With Malignant Bowel Obstruction Caused By Cancer
A Pilot Study of Nicotine for "Hunger Pain" in Patients With Bowel Obstruction From Incurable Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): No patient enrollment occurred.
Summary
Brief summary (as posted)
RATIONALE: The use of a nicotine inhaler may help decrease appetite and relieve "hunger pain" (an intense craving for food) in patients with malignant bowel obstruction caused by cancer. PURPOSE: This randomized clinical trial is studying the side effects and how well a nicotine inhaler works in treating "hunger pain" in patients with malignant bowel obstruction caused by cancer.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anorexia | — | UNRESOLVED | — |
| Constipation, Impaction, and Bowel Obstruction | — | UNRESOLVED | — |
| Pain | — | UNRESOLVED | — |
| Psychosocial Effects of Cancer and Its Treatment | — | UNRESOLVED | — |
| Unspecified Adult Solid Tumor, Protocol Specific | Adult Solid Neoplasm | ALIAS | 0.85 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| nicotine | Drug | — | UNRESOLVED |
| Placebo | Other | — | UNRESOLVED |
| Quality of life | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Nicotine inhaler
- interventionNames
- Drug: nicotine
- Procedure: Quality of life
- type
- PLACEBO_COMPARATOR
- label
- Placebo inhaler
- interventionNames
- Other: Placebo
- Procedure: Quality of life
Primary outcomes (1)
- measure
- Determination of whether ≥ 50% of patients utilize nicotine for treating "hunger pain" ≥ 2 times over a 48-hour period
- timeFrame
- 48 Hours
Secondary outcomes (4)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 120 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Diagnosis of any incurable malignancy * Presence of malignant bowel obstruction * Must be on strict "nothing per os" (NPO) status over the next 48 hours * Ice chips allowed * Acknowledges that "hunger pain" is a problem PATIENT CHARACTERISTICS: * Mentally competent * No history of life-threatening arrhythmia * No severe or worsening angina * No accelerated hypertension * No known hypersensitivity to nicotine * Not pregnant or nursing * Negative pregnancy test PRIOR CONCURRENT THERAPY: * Concurrent short-term use of dexamethasone or other hormonal therapy or symptom control strategy allowed
References
Publications (0)
Data not yet available