Clinical trial · Interventional
Multiple Dose Study of MPC-6827 in Subjects With Refractory Brain Metastases
Phase 1 Open Label, Dose Escalating, Multiple Dose Study to Determine the Safety, Tolerability, Maximum Tolerated Dose, and Pharmacokinetics of MPC-6827 Administered IV Weekly X 3, Repeated Every 28 Days, in Subjects With Refractory Brain Metastases
NCT00393965CI-TRIAL-00001152completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Phase 1, Multiple dose Study of MPC-6827 in Subjects with Refractory Brain Metastases.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasms | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MPC-6827 | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Maximum Tolerated Dose
- timeFrame
- 1 year
- measure
- Pharmacokinetics
- timeFrame
- 1 year
Secondary outcomes (1)
- measure
- Antitumor Activity
- timeFrame
- 2 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Refractory Brain Metastases * At least 1 measurable intracranial lesion as defined by RECIST * ECOG less than or equal to 1 * Adequate hematology/organ function * No baseline peripheral or central neuropathy above grade 1 Exclusion Criteria: * Hypersensitivity to Cremophor EL * Pregnant or Lactating * Spinal Cord Compression * Pre-existing dementia/cognitive disfunction * Require Neupogen or Neulasta to Maintain Neutrophil Count * Have Primary Brain Cancer * Have History of Ischemic Heart Disease * Have Diabetes
References
Publications (0)
Data not yet available
No reference posted for this study.